Prevalence of Metabolic Syndrome in Patients With Rheumatoid Arthritis: An Updated Systematic Review and Meta-Analysis

作者全名："Cai, Wei; Tang, Xuemi; Pang, Min"

作者地址："[Cai, Wei] Huazhong Univ Sci & Technol, Pediat Dept, Union Shenzhen Hosp, Shenzhen, Peoples R China; [Tang, Xuemi; Pang, Min] Chongqing Med Univ, Dept Rheumatol & Immunol, Childrens Hosp, Chongqing, Peoples R China"

通信作者："Cai, W (通讯作者)，Huazhong Univ Sci & Technol, Pediat Dept, Union Shenzhen Hosp, Shenzhen, Peoples R China."

来源：FRONTIERS IN MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000792768400001

JCR分区：Q1

影响因子：3.9

年份：2022

卷号：9

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：metabolic syndrome; rheumatoid arthritis; prevalence; systematic review; meta-analysis

摘要："Introduction: Rheumatoid arthritis (RA) due to systemic inflammation and insulin resistance increases the risk of cardiovascular disease and reduces life expectancy. In order to develop cardiac death prevention strategies, it is necessary to estimate the prevalence of metabolic syndrome (MetS) in these patients.& nbsp;Methods: This systematic review and meta-analysis was performed to estimate the prevalence of MetS among patients with RA. International databases (i.e., Scopus, PubMed, Web of Science, and Google Scholar) were searched during the period of October 1 and October 10, 20121. Heterogeneity among the included studies was assessed through the Cochrane Q test statistics and I-2 test. Finally, a random-effects meta-analysis model was computed to estimate the pooled prevalence of MetS.& nbsp;Results: Sixty-one articles with 96 groups and a sample size of 13,644 people were analyzed. The pooled prevalence of MetS was 32% (95% CI: 29.6-34.4). The highest prevalence of MetS is related to studies conducted in Asia (32.7%, 95% CI: 29-36.3) and Europe (32.7%, 95% CI: 27.5.37.9) and the lowest Prevalence was also related to studies conducted in Africa (28%, 95% CI: 28.8-32.2). The prevalence of MetS in men was 33% (95% CI: 26-39) and 34% (95% CI: 29-40) in women. Findings by diagnostic criteria showed that the highest and lowest prevalence of MetS was related to ATP III (37.5%, 95% CI: 30.9-44.2) and EGIR (14.4%, 95% CI: 10.5-18.5), respectively.& nbsp;Conclusions: MetS is highly prevalent in patients with RA and identification of high-risk patients is necessary to prevent cardiovascular mortality."

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