Bi-PAP is not superior to NCPAP in the premature twins with respiratory distress syndrome: a prospective cohort study

作者全名："Deng, Xingmei; Cao, Huiling; Zhang, Chunxiu; Yang, Hong; Shi, Yuan; Li, Fang; Li, Chuanfeng"

作者地址："[Deng, Xingmei; Zhang, Chunxiu; Yang, Hong; Li, Chuanfeng] Qujing Maternal & Child Hlth Hosp, Dept Pediat, Qujing 655000, Yunnan, Peoples R China; [Cao, Huiling; Shi, Yuan; Li, Fang] Chongqing Med Univ, Childrens Hosp, Dept Neonatol, Chongqing 400000, Peoples R China; [Cao, Huiling; Shi, Yuan; Li, Fang] Natl Clin Res Ctr Child Hlth & Disorders, Chongqing 400000, Peoples R China; [Cao, Huiling; Shi, Yuan; Li, Fang] Minist Educ, Key Lab Child Dev & Disorders, Chongqing 400000, Peoples R China; [Cao, Huiling; Shi, Yuan; Li, Fang] China Int Sci & Technol Cooperat Base Child Dev &, Chongqing 400000, Peoples R China; [Cao, Huiling; Shi, Yuan; Li, Fang] Chongqing Key Lab Pediat, Chongqing 400000, Peoples R China"

通信作者："Li, CF (通讯作者)，Qujing Maternal & Child Hlth Hosp, Dept Pediat, Qujing 655000, Yunnan, Peoples R China.; Li, F (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Neonatol, Chongqing 400000, Peoples R China.; Li, F (通讯作者)，Natl Clin Res Ctr Child Hlth & Disorders, Chongqing 400000, Peoples R China.; Li, F (通讯作者)，Minist Educ, Key Lab Child Dev & Disorders, Chongqing 400000, Peoples R China.; Li, F (通讯作者)，China Int Sci & Technol Cooperat Base Child Dev &, Chongqing 400000, Peoples R China.; Li, F (通讯作者)，Chongqing Key Lab Pediat, Chongqing 400000, Peoples R China."

来源：CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000792911600019

JCR分区：Q4

影响因子：0.2

年份：2022

卷号：49

期号：4

开始页：　

结束页：　

文献类型：Article

关键词：respiratory distress syndrome; bi-level positive airway pressure; nasal continuous positive airway pressure; preterm twins

摘要："Background: Recently, non-invasive ventilation has been widely used due to the reduction of adverse effects of endotracheal intubation. Nevertheless nearly no researches have compared the efficacy of non-invasive respiratory support between preterm twins. The objective of this study was to determine if there is a decreased non-invasive ventilation (NW) failure from bi-level positive airway pressure (Bi-PAP) vs nasal continuous positive airway pressure (NCPAP) in preterm twins as initial ventilation. Methods: This prospective cohort study enrolled 100 pairs preterm twins who were admitted to the NICU at Yunnan Qujing Maternity and Child Health Care Hospital from 2017.10 to 2020.09 for respiratory distress syndrome. One of the twin was randomly assigned to Bi-PAP, meanwhile another to NCPAP. The primary outcome was the incidence of NIV failure. Secondary outcomes was the occurrence rate of side-effects of NIV. Results: A total of 100 pairs preterm twins were included in statistical analysis. No distinct differences were found in NIV failure between groups (NCPAP vs Hi-PAP, 5% vs 2%, p = 0.248). We did not find any statistical difference in secondary outcome between Iii-PAP and NCPAP. Conclusions: In this prospective cohort study, among preterm twins with IDS, NCPAP was noninferior to Hi-PAP with respect to the reduction of the need for invasive mechanical ventilation (IMV)."

基金机构：National Natural Science Foundation of China [81401236]; Natural Science Foundation of Chongqing [cstc2021jcyj-msxmX0257]; Science and health project of Chongqing Health Commission [2021MSXM202]; Chongqing Educational Commission [KJQN201800410]

基金资助正文："This work was supported by National Natural Science Foundation of China (NO.81401236), Natural Science Foundation of Chongqing (cstc2021jcyj-msxmX0257), Science and health project of Chongqing Health Commission (NO.2021MSXM202), project of Chongqing Educational Commission (KJQN201800410)."