Construction and validation of a prognostic model for stage IIIC endometrial cancer patients after surgery

作者全名："Yang, Xi-Lin; Huang, Hong; Kou, Ling-Na; Lai, Hua; Chen, Xiao-Pin; Wu, Da-Jun"

作者地址："[Yang, Xi-Lin; Huang, Hong; Wu, Da-Jun] Univ Elect Sci & Technol China, Chengdu Womens & Childrens Cent Hosp, Sch Med, Dept Radiat Oncol, Chengdu 611731, Peoples R China; [Kou, Ling-Na] Sichuan Canc Hosp & Inst, Dept Med Oncol, Chengdu 610042, Peoples R China; [Lai, Hua] Univ Elect Sci & Technol China, Chengdu Womens & Childrens Cent Hosp, Sch Med, Dept Radiol, Chengdu 611731, Peoples R China; [Chen, Xiao-Pin] Chongqing Med Univ, Dept Oncol, Affiliated Hosp 1, Chongqing 400000, Peoples R China"

通信作者："Lai, H; Wu, DJ (通讯作者)，1617 Riyue Ave, Chengdu 611731, Peoples R China.; Chen, XP (通讯作者)，1 Youyi Rd, Chongqing 400000, Peoples R China."

来源：EJSO

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000792912800031

JCR分区：Q1

影响因子：3.8

年份：2022

卷号：48

期号：5

开始页：1173

结束页：1180

文献类型：Article

关键词：Endometrial cancer; Stage IIIC; Nomogram; SEER; Prognosis

摘要："Background: To explore the most predictive lymph node (LN) scheme for stage IIIC endometrial cancer (EC) patients after hysterectomy and develop a scheme-based nomogram. Methods: Data from 2626 stage IIIC EC patients, diagnosed between 2010 and 2014, were extracted from the Surveillance, Epidemiology, and End Results (SEER) registry. The predictive ability of four LN schemes was assessed using C-index and Akaike information criterion (AIC). A nomogram based on the most predictive LN scheme was constructed and validated. The comparison of the predictive ability between nomogram and FIGO stage was conducted using the area under the receiver operating characteristic curve (AUC) and decision curve analysis (DCA). Results: FIGO stage (stage IIIC1/stage IIIC2) was not an independent risk factor for OS in stage IIIC EC patients (P = 0.672) and log odds of positive lymph nodes (LODDS) had the best predictive ability (C-index: 0.742; AIC: 8228.95). A nomogram based on LODDS was constructed and validated, which had a decent C-index of 0.742 (0.723-0.762). The nomogram showed a better predictive ability than that of the FIGO staging system. Conclusion: FIGO IIIC1/FIGO IIIC2 could not differentiate the prognosis for stage IIIC EC patients. We developed and validated a nomogram based on LODDS to predict OS for post-operative patients with stage IIIC EC. (C) 2021 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved."

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