Effect of polymer terminal groups on the drug release and experimental characterization of an electrospun naringin-loaded microsphere/sucrose acetate isobutyrate (SAIB) depot

作者全名："Liao, Hang; Zhang, Ting; Song, Jinlin; Li, Jihong; Yi, Yin; Meng, Di; Shu, Yu; Wu, Xiaohong"

作者地址："[Liao, Hang; Zhang, Ting; Song, Jinlin; Li, Jihong; Yi, Yin; Meng, Di; Shu, Yu; Wu, Xiaohong] Stomatol Hosp Chongqing Med Univ, 426 Songshibei Rd, Yubei Dist, Chongqing 401147, Peoples R China; [Liao, Hang; Zhang, Ting; Song, Jinlin; Li, Jihong; Yi, Yin; Meng, Di; Shu, Yu; Wu, Xiaohong] Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 401147, Peoples R China; [Liao, Hang; Zhang, Ting; Song, Jinlin; Li, Jihong; Yi, Yin; Meng, Di; Shu, Yu; Wu, Xiaohong] Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401147, Peoples R China"

通信作者："Wu, XH (通讯作者)，Stomatol Hosp Chongqing Med Univ, 426 Songshibei Rd, Yubei Dist, Chongqing 401147, Peoples R China.; Wu, XH (通讯作者)，Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 401147, Peoples R China.; Wu, XH (通讯作者)，Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401147, Peoples R China."

来源：MATERIALS LETTERS

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000793250500001

JCR分区：Q2

影响因子：3

年份：2022

卷号：318

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Biomaterials; Polymeric composites; FTIR; Polymers; Particles; Nanosize

摘要："The study was designed to develop an improved in situ injection drug delivery system by preparing naringin (Ng) loaded electrospray microspheres with different terminal groups PLGA and studying their effect on drug release and related properties of naringin-loaded electrospray microspheres/sucrose acetate isobutyrate (Ng-m-SAIB) depot. The electrospray technique was used to prepare microspheres, that were characterized for their shapes and size distribution, as well as the related properties of the Ng-m-SAIB depot were tested. The initial drug release rate of hydroxyl-terminated microspheres (OH-Ng-m) was lower than that of carboxyl-terminated microspheres (COOH-Ng-m) and ester-terminated microspheres (COOR-Ng-m). The burst release, on the first day after preparing the mixed depots of OH-/COOH/COOR-Ng-m-SAIB, was significantly decreased from 43.9%, 47.4%, and 56.1% to 1.6%, 2.4%, and 3.9%, respectively. During the 88-day release profile, OH-Ng-m-SAIB had a low drug release (1.39% per day) in the early stage, yet maintained a relatively stable drug release. These findings suggest that by modifying the PLGA terminal groups in electrospray microspheres, the drug release profile of Ng-m-SAIB depot can be effectively tailored."

基金机构：National Natural Science Foundation of China [81970914]

基金资助正文：We greatly appreciate the support from the National Natural Science Foundation of China (No. 81970914).