Anti-nuclear matrix protein 2+juvenile dermatomyositis with severe skin ulcer and infection: A case report and literature review

作者全名："Wang, Ya-Ting; Zhang, Yu; Tang, Tao; Luo, Chong; Liu, Ming-Yue; Xu, Li; Wang, Li; Tang, Xue-Mei"

作者地址："[Wang, Ya-Ting; Zhang, Yu; Tang, Tao; Luo, Chong; Liu, Ming-Yue; Xu, Li; Wang, Li; Tang, Xue-Mei] Chongqing Med Univ, Dept Rheumatol & Immunol, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China; [Wang, Ya-Ting; Zhang, Yu; Tang, Tao; Luo, Chong; Liu, Ming-Yue; Xu, Li; Wang, Li; Tang, Xue-Mei] Chongqing Med Univ, Minist Educ, Key Lab Child Dev & Disorders, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China; [Wang, Ya-Ting; Zhang, Yu; Tang, Tao; Luo, Chong; Liu, Ming-Yue; Xu, Li; Wang, Li; Tang, Xue-Mei] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders Chongqin, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China; [Wang, Ya-Ting; Zhang, Yu; Tang, Tao; Luo, Chong; Liu, Ming-Yue; Xu, Li; Wang, Li; Tang, Xue-Mei] Chongqing Med Univ, China Int Sci & Technol Cooperat Base Child Dev &, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China; [Wang, Ya-Ting; Zhang, Yu; Tang, Tao; Luo, Chong; Liu, Ming-Yue; Xu, Li; Wang, Li; Tang, Xue-Mei] Chongqing Med Univ, Childrens Hosp, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China; [Wang, Ya-Ting; Zhang, Yu; Tang, Tao; Luo, Chong; Liu, Ming-Yue; Xu, Li; Wang, Li; Tang, Xue-Mei] Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Child Infect & Immun, Chongqing 400014, Peoples R China"

通信作者："Tang, XM (通讯作者)，Chongqing Med Univ, Dept Rheumatol & Immunol, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China.; Tang, XM (通讯作者)，Chongqing Med Univ, Minist Educ, Key Lab Child Dev & Disorders, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China.; Tang, XM (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders Chongqin, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China.; Tang, XM (通讯作者)，Chongqing Med Univ, China Int Sci & Technol Cooperat Base Child Dev &, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China.; Tang, XM (通讯作者)，Chongqing Med Univ, Childrens Hosp, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China."

来源：WORLD JOURNAL OF CLINICAL CASES

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000793515400028

JCR分区：Q3

影响因子：1.1

年份：2022

卷号：10

期号：11

开始页：3579

结束页：3586

文献类型：Review

关键词：Juvenile dermatomyositis; Skin ulcer; Anti-nuclear matrix protein 2 antibody; Case report

摘要："BACKGROUND Juvenile dermatomyositis (JDM) is an idiopathic inflammatory myopathy that occurs in childhood. It is characterized by muscle weakness and a characteristic rash. Previous literature reports have rarely described JDM with severe skin ulcers and infections. CASE SUMMARY Herein, we describe a case of a 2-year-old female patient who suffered from JDM, whose myositis-specific autoantibodies were positive for anti-nuclear matrix protein 2 antibody, with progressively worsening skin ulcers and severe infections. The patient was treated with glucocorticoids and various immunosuppressants. Nevertheless, further progression of the disease and the combination of primary disease and severe infection in the later period were fatal. CONCLUSION In children, anti-nuclear matrix protein 2+ JDM combined with skin ulcers often indicates severe disease. In such cases, personalized treatment for the primary disease and infection prevention and control are essential."

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