The Causal Association Between Obesity and Primary Open-Angle Glaucoma: A Two-Sample Mendelian Randomization Study

作者全名："Lin, Yi; Zhu, Xiaomin; Luo, Wangdu; Jiang, Bingcai; Lin, Qianyi; Tang, Min; Li, Xiangji; Xie, Lin"

作者地址："[Lin, Yi; Zhu, Xiaomin; Luo, Wangdu; Jiang, Bingcai; Lin, Qianyi; Tang, Min; Li, Xiangji; Xie, Lin] Chongqing Med Univ, Dept Ophthalmol, Affiliated Hosp 3, Chongqing, Peoples R China"

通信作者："Xie, L (通讯作者)，Chongqing Med Univ, Dept Ophthalmol, Affiliated Hosp 3, Chongqing, Peoples R China."

来源：FRONTIERS IN GENETICS

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000793833000001

JCR分区：Q2

影响因子：3.7

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：primary open-angle glaucoma; body mass index; waist circumference; hip circumference; Mendelian randomization

摘要："The correlation between obesity and primary open-angle glaucoma (POAG) has not yet been fully established. The aim of this study was to investigate the causal relationship between obesity and POAG by a two-sample Mendelian randomization (MR) study. In this study, body mass index (BMI), an index to evaluate general obesity, and waist and hip circumference, indices to evaluate abdominal obesity, were selected as exposures in MR analysis. Single-nucleotide polymorphisms (SNPs) were chosen as instrumental variables (IVs). Summary data from genome-wide association studies (GWASs) based on a European ancestry by Locke et al., with regard to BMI, and Shungin et al., with regard to waist and hip circumference, were used. Genetic predictors of POAG were obtained from public GWAS summary data. To assess the causal effect of obesity on POAG, the inverse variance-weighted (IVW) method was used as the primary method, and other methods, such as MR-Egger, weighted median, simple mode, and weighted mode, were also used as complementary analyses. Finally, we performed Cochran's Q statistic to assess heterogeneity, and sensitivity analysis was performed to evaluate the reliability and stability of the MR results. MR analysis showed that BMI has a positive effect on the risk of POAG, with 1 standard deviation (SD) increase in BMI; the risk of POAG increases by approximately 90.9% [OR = 1.909; 95% CI= (1.225, 2.975); p = 0.0042)] (analyzed by IVW); there were no heterogeneity and pleiotropy in the result; and waist circumference also had a positive effect on the risk of POAG [OR = 2.319; 95% CI= (1.071, 5.018); p = 0.033)] analyzed by weighted median. As hip circumference increases, with 1 SD increase in hip circumference, the risk of POAG increases by approximately 119% [OR = 2.199; 95% CI= (1.306, 3.703); p = 0.00305)] estimated by IVW, there were not heterogeneity and pleiotropy as for the result. Our study for the first time confirms that obesity might increase the risk of POAG using two-sample MR analysis. These results might provide guidance on the prevention and treatment of POAG."

基金机构："Natural Science Foundation of China [81470629, 81670860]; Chongqing Natural Research Foundation [cstc 2018jcyjAX0034]"

基金资助正文："& nbsp;The research work was supported by the Natural Science Foundation of China (Grant Nos 81470629 and 81670860; Chongqing, China) and Chongqing Natural Research Foundation (No. cstc 2018jcyjAX0034; Chongqing, China)."