Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke

作者全名："Zhou, Li; Zhu, Huimin; Bai, Xue; Huang, Jiagui; Chen, Yue; Wen, Jun; Li, Xuemei; Wu, Bowen; Tan, Yongjun; Tian, Mingfen; Ren, Jiangxia; Li, Mengxia; Yang, Qin"

作者地址："[Zhou, Li; Zhu, Huimin; Bai, Xue; Huang, Jiagui; Chen, Yue; Wen, Jun; Li, Xuemei; Wu, Bowen; Tan, Yongjun; Tian, Mingfen; Ren, Jiangxia; Li, Mengxia; Yang, Qin] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Bai, Xue] First Peoples Hosp Neijiang, Dept Neurol, Neijiang 64100, Sichuan, Peoples R China"

通信作者："Yang, Q (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：STEM CELL RESEARCH & THERAPY

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000794877600001

JCR分区：Q1

影响因子：7.5

年份：2022

卷号：13

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：Mesenchymal stem cells; Ischemic stroke; Stem cell transplantation; Therapeutic targets; Regenerative medicine

摘要："Ischemic stroke is one of the major causes of death and disability in the world. Currently, most patients cannot choose intravenous thrombolysis or intravascular mechanical thrombectomy because of narrow therapeutic windows and severe complications. Stem cell transplantation is an emerging treatment and has been studied in various central nervous system diseases. Animal and clinical studies showed that transplantation of mesenchymal stem cells (MSCs) could alleviate neurological deficits and bring hope for ischemic stroke treatment. This article reviewed biological characteristics, safety, feasibility and efficacy of MSCs therapy, potential therapeutic targets of MSCs, and production process of Good Manufacturing Practices-grade MSCs, to explore the potential therapeutic targets of MSCs in the process of production and use and provide new therapeutic directions for ischemic stroke."

基金机构：National Natural Science Foundation of China

基金资助正文：This work was supported by the National Natural Science Foundation of China.