Targeting Mitochondrial Oxidative Phosphorylation Eradicates Acute Myeloid Leukemic Stem Cells

作者全名："Peng, Meixi; Huang, Yongxiu; Zhang, Ling; Zhao, Xueya; Hou, Yu"

作者地址："[Peng, Meixi; Zhao, Xueya; Hou, Yu] Chongqing Med Univ, Biol Sci Inst, Chongqing, Peoples R China; [Huang, Yongxiu] Third Mil Med Univ, Army Med Univ, Clin Hematol, Chongqing, Peoples R China; [Huang, Yongxiu] Chongqing Univ, Sch Med, Chongqing, Peoples R China; [Zhang, Ling] Chongqing Med Univ, Sch Lab Med, Key Lab Lab Med Diagnost Designated, Minist Educ, Chongqing, Peoples R China"

通信作者："Hou, Y (通讯作者)，Chongqing Med Univ, Biol Sci Inst, Chongqing, Peoples R China."

来源：FRONTIERS IN ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000795706500001

JCR分区：Q2

影响因子：4.7

年份：2022

卷号：12

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：leukemic stem cells (LSCs); oxidative phosphorylation (OXPHOS); electron transport chain; tricarboxylic acid cycle (TCA cycle); mitochondria

摘要："Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by multiple cytogenetic and molecular abnormalities, with a very poor prognosis. Current treatments for AML often fail to eliminate leukemic stem cells (LSCs), which perpetuate the disease. LSCs exhibit a unique metabolic profile, especially dependent on oxidative phosphorylation (OXPHOS) for energy production. Whereas, normal hematopoietic stem cells (HSCs) and leukemic blasts rely on glycolysis for adenosine triphosphate (ATP) production. Thus, understanding the regulation of OXPHOS in LSCs may offer effective targets for developing clinical therapies in AML. This review summarizes these studies with a focus on the regulation of the electron transport chain (ETC) and tricarboxylic acid (TCA) cycle in OXPHOS and discusses potential therapies for eliminating LSCs."

基金机构："National Natural Science Foundation of China [82170115, 1900588]"

基金资助正文：Funding This work was supported by grants from the National Natural Science Foundation of China (Grant No. 82170115 and No. 1900588).