Clinical characteristics of COVID-19 in young patients differ from middle-aged and elderly patients

作者全名："Wan, Keqiang; Su, Chang; Kong, Lingxi; Liao, Juan; Tian, Wenguang; Luo, Hua"

作者地址："[Wan, Keqiang; Su, Chang; Kong, Lingxi; Tian, Wenguang] Chongqing Med Univ, Dept Infect Dis, Yongchuan Hosp, Chongqing, Peoples R China; [Liao, Juan] Chongqing Med Univ, Cent Lab, Yongchuan Hosp, Chongqing, Peoples R China; [Luo, Hua] Chongqing Med Univ, Dept Resp & Crit Care Med, YongChuan Hosp, Chongqing, Peoples R China"

通信作者："Luo, H (通讯作者)，Chongqing Med Univ, Dept Resp & Crit Care Med, YongChuan Hosp, Chongqing, Peoples R China."

来源：ARCHIVES OF MEDICAL SCIENCE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000795873300017

JCR分区：Q1

影响因子：3.8

年份：2022

卷号：18

期号：3

开始页：704

结束页：710

文献类型：Article

关键词：COVID-19; western Chongqing; young patients; clinical characteristics

摘要："Introduction: Coronavirus disease-2019 (COVID-19) has spread worldwide. The study aimed to understand the clinical characteristics of young COVID-19 patients. Material and methods: Ninety patients with severe COVID-19 infection in western Chongqing were collected from 21 January to 14 March 2020. They were divided into 4 groups based on age: youth ( 39 years), middle-aged (39???48 years), middle-elderly aged (49???60 years), and elderly ( 60 years). The clinical symptoms, laboratory findings, imaging findings, and treatment effects were compared among the groups. Results: There were 22, 27, 19, and 22 cases in the youth, middle-aged, middle-elderly, and elderly groups, respectively. There were no significant differences with respect to gender or smoking status among the four groups. The clinical indicators of severe disease in the youth group were significantly different from the other three groups, and included the lymphocyte count (p < 0.001), C-reactive protein level (p = 0.03), interleukin-6 level (p = 0.01), chest computed tomography (CT) findings (p < 0.001), number of mild cases (p = 0.02), education level (p < 0.001), and CD4 + T lymphocyte level (p = 0.02) at the time of admission, and the pneumonia severity index (PSI) at the time of discharge (p < 0.001). The complications (p < 0.001) among the youth group were also significantly different from the other groups. Conclusions: Young patients have milder clinical manifestations, which may be related to higher education level, higher awareness and higher acceptance of the prevention and control of the COVID-19 epidemic, as well as their good immune function."

基金机构："Science and Technology Bureau of Yongchuan District, Chongqing"

基金资助正文："The authors would like to thank Liao Juan, a researcher from Yongchuan Hospital affiliated with Chongqing Medical University, for her guidance on the statistical methods in the manuscript, and thanks to Professor Tian Wenguang from Yongchuan Hospital affiliated with Chongqing Medical University for revising the manuscript! We would like to thank the Science and Technology Bureau of Yongchuan District, Chongqing for financial support of the research. Lastly, sincere appreciation is extended to all novel coronavirus prevention and control personnel on the front line."