"Association Between Diabetes Risk Reduction Diet and Lung Cancer Risk in 98,159 Participants: Results From a Prospective Study"

作者全名："Zhang, Yin; Zhong, Guochao; Zhu, Min; Chen, Ling; Wan, Huajing; Luo, Fengming"

作者地址："[Zhang, Yin; Zhu, Min; Chen, Ling; Wan, Huajing; Luo, Fengming] Sichuan Univ, West China Hosp, Dept Resp & Crit Care Med, Chengdu, Peoples R China; [Zhang, Yin; Zhu, Min; Chen, Ling; Wan, Huajing; Luo, Fengming] Sichuan Univ, West China Hosp, Frontiers Sci Ctr Dis Related Mol Network, Lab Pulm Immunol & Inflammat, Chengdu, Peoples R China; [Zhang, Yin; Zhu, Min; Chen, Ling; Wan, Huajing; Luo, Fengming] Sichuan Univ, West China Hosp, Clin Res Ctr Resp Dis, Chengdu, Peoples R China; [Zhong, Guochao] Chongqing Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 2, Chongqing, Peoples R China"

通信作者："Wan, HJ; Luo, FM (通讯作者)，Sichuan Univ, West China Hosp, Dept Resp & Crit Care Med, Chengdu, Peoples R China.; Wan, HJ; Luo, FM (通讯作者)，Sichuan Univ, West China Hosp, Frontiers Sci Ctr Dis Related Mol Network, Lab Pulm Immunol & Inflammat, Chengdu, Peoples R China.; Wan, HJ; Luo, FM (通讯作者)，Sichuan Univ, West China Hosp, Clin Res Ctr Resp Dis, Chengdu, Peoples R China."

来源：FRONTIERS IN ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000795885400001

JCR分区：Q2

影响因子：4.7

年份：2022

卷号：12

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：diabetes risk reduction diet score; lung cancer; prevention; prostate lung colorectal and ovarian cancer screening trial; dose; response

摘要："PurposeTo evaluate the association between diabetes risk reduction diet (DRRD) score and the risk of lung cancer in a large population. MethodsData of participants in this study were collected from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated in the Cox proportional hazards regression model for the association of DRRD score and lung cancer incidence in all included participants. Prespecified subgroup analyses were performed to evaluate whether the observed association was modified by age, sex, BMI, race/ethnicity, family history of lung cancer, smoking status and history of diabetes. ResultsA total of 98,159 participants were included in this study. The mean (SD) age of the study participants cohort at baseline was 65.5 (5.73) years old. The mean (SD) follow-up time was 8.83 (1.96) years. The mean (SD) score of DRRD was 26.82 (5.19), and ranged from 20.47 (2.3) to 33.65 (2.42) from the lowest quartile to the highest quartile of the DRRD score, inferring the possibility of highest through the lowest risk of type 2 diabetes. The calculated HRs showed there was a trend that higher quartile indicated lower risk of lung cancer after adjusted for covariates (HRQ4vsQ1: 0.85; 95% CI:0.73,0.98; p for trend =0.036). The inverse trend between higher DRRD score and the risk of squamous cell carcinoma was more evident (HRQ4vsQ1: 0.50; 95% CI:0.34,0.73; p for trend =0.002). The inverse association between DRRD score and the incidence of lung cancer was more pronounced in participants who had a clear family history of lung cancer (p for interaction=0.016). ConclusionA protective association between DRRD score and risk of lung cancer is obtained. People are encouraged to adhere to higher DRRD score in their daily diet. Further studies should be conducted to confirm the result and explore the mechanism."

基金机构："National Natural Science Foundation of China [32070764, 81800087]; 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University [ZYJC18021]; Sichuan Science and Technology Program [2021YFQ0030]"

基金资助正文："This work was supported by National Natural Science Foundation of China grant (NSFC No.32070764; No.81800087); 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (ZYJC18021); Sichuan Science and Technology Program (No.2021YFQ0030)."