"Epidemiological Evidence Between Variants in Matrix Metalloproteinases-2,-7, and-9 and Cancer Risk"

作者全名："Huang, Chenglu; Xu, Suqin; Luo, Zhilin; Li, Dong; Wang, Rui; Wang, Tianhu"

作者地址："[Huang, Chenglu; Luo, Zhilin; Li, Dong; Wang, Rui; Wang, Tianhu] Chongqing Med Univ, Affiliated Hosp 3, Dept Thorac Surg, Chongqing, Peoples R China; [Xu, Suqin] Chongqing Univ Canc Hosp, Dept Radiol, Chongqing, Peoples R China"

通信作者："Wang, TH (通讯作者)，Chongqing Med Univ, Affiliated Hosp 3, Dept Thorac Surg, Chongqing, Peoples R China."

来源：FRONTIERS IN ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000795921500001

JCR分区：Q2

影响因子：4.7

年份：2022

卷号：12

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：matrix metalloproteinases; variant; meta-analysis; gene; cancer

摘要："Background:& nbsp;Matrix metalloproteinases (MMPs), a kind of proteases, have a critical function in cancer occurrence, invasion, and migration. MMP gene variants (e.g., MMP-2, MMP-7, and MMP-9) can affect the biological functions of these enzymes and lead to the occurrence and progression of cancer, which has become a hot topic in recent years, but the corresponding results are still controversial. In this context, here, the meta-analysis was conducted for assessing the relations of variants in MMP-2, MMP-7, and MMP-9 with the risk of various cancers.& nbsp;Methods:& nbsp;PubMed, Web of Science, and Medline were systemically searched, and data were extracted from all eligible studies so as to investigate the susceptibility of MMP-2, MMP-7, and MMP-9 to different types of cancers. The association between a variant in MMP and cancer susceptibility was analyzed through odds ratios (ORs) as well as 95% CIs. The Venice criteria and false-positive report probability (FPRP) were adopted to evaluate epidemiological evidence of significant associations discovered.& nbsp;Results:& nbsp;The associations between the variants of MMPs and cancer risk in 36,530 cases and 41,258 controls were found, with 12 associations (MMP-2 rs243865 with esophageal cancer and lung cancer, MMP-7 rs11568818 with bladder and cervical cancer, and MMP-9 rs3918242 with breast cancer) rated as strong associations for cancer risk and 7 and 15 as moderate and weak associations, respectively. These significant associations were mostly found in Asians.& nbsp;Conclusions:& nbsp;These findings support the relations between variants of MMP-2, MMP-7, and MMP-9 and various cancers risk, demonstrating the credibility of these relations."

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