White Matter Injury in Preterm Infants: Pathogenesis and Potential Therapy From the Aspect of the Gut-Brain Axis

作者全名："He, Yu; Zhang, Yuni; Li, Fang; Shi, Yuan"

作者地址："[He, Yu; Zhang, Yuni; Li, Fang; Shi, Yuan] Chongqing Med Univ, Dept Neonatol, Childrens Hosp, Chongqing, Peoples R China; [He, Yu; Zhang, Yuni; Li, Fang; Shi, Yuan] Chongqing Med Univ, Chongqing Key Lab Pediat, Childrens Hosp, Chongqing, Peoples R China; [He, Yu; Zhang, Yuni; Li, Fang; Shi, Yuan] Minist Educ, Natl Clin Res Ctr Child Hlth & Disorders, China Int Sci & Technol Cooperat Base Child Dev &, Key Lab Child Dev & Disorders, Chongqing, Peoples R China"

通信作者："Li, F; Shi, Y (通讯作者)，Chongqing Med Univ, Dept Neonatol, Childrens Hosp, Chongqing, Peoples R China.; Li, F; Shi, Y (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Pediat, Childrens Hosp, Chongqing, Peoples R China.; Li, F; Shi, Y (通讯作者)，Minist Educ, Natl Clin Res Ctr Child Hlth & Disorders, China Int Sci & Technol Cooperat Base Child Dev &, Key Lab Child Dev & Disorders, Chongqing, Peoples R China."

来源：FRONTIERS IN NEUROSCIENCE

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000796199600001

JCR分区：Q2

影响因子：4.3

年份：2022

卷号：16

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：white matter injury; oligodendrocyte precursor cells; hypomyelination; microglia; inflammation; short-chain fatty acids

摘要："Very preterm infants who survive are at high risk of white matter injury (WMI). With a greater understanding of the pathogenesis of WMI, the gut microbiota has recently drawn increasing attention in this field. This review tries to clarify the possible mechanisms behind the communication of the gut bacteria and the immature brain via the gut-brain axis. The gut microbiota releases signals, such as microbial metabolites. These metabolites regulate inflammatory and immune responses characterized by microglial activation, which ultimately impact the differentiation of pre-myelinating oligodendrocytes (pre-OLs) and lead to WMI. Moreover, probiotics and prebiotics emerge as a promising therapy to improve the neurodevelopmental outcome. However, future studies are required to clarify the function of these above products and the optimal time for their administration within a larger population. Based on the existing evidence, it is still too early to recommend probiotics and prebiotics as effective treatments for WMI."

基金机构："National Natural Science Foundation of China [81401236, 82001602]; Natural Science Foundation of Chongqing [cstc2021jcyj-msxmX0257]; Science and Health Project of Chongqing Health Commission [2021MSXM202, 2020FYYX217]; Project of Chongqing Educational Commission [KJQN20 1800410]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (Nos. 81401236 and 82001602), the Natural Science Foundation of Chongqing (cstc2021jcyj-msxmX0257), the Science and Health Project of Chongqing Health Commission (Nos. 2021MSXM202 and 2020FYYX217), and the Project of Chongqing Educational Commission (KJQN20 1800410)."