Effects of Pramipexole Combined with Nerve Growth Factor on Cognitive Impairment and Urinary AD7c-NTP Expression in Patients with Parkinson's Disease

作者全名："Wang, Zhengxin; Cheng, Saiyu"

作者地址："[Wang, Zhengxin; Cheng, Saiyu] Chongqing Med Univ, Dept Neurol & Neurosurg, Affiliated Hosp 3, Chongqing 401120, Peoples R China"

通信作者："Cheng, SY (通讯作者)，Chongqing Med Univ, Dept Neurol & Neurosurg, Affiliated Hosp 3, Chongqing 401120, Peoples R China."

来源：COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE

ESI学科分类：MATHEMATICS

WOS号：WOS:000796888100004

JCR分区：Q2

影响因子：2.809

年份：2022

卷号：2022

期号：　

开始页：　

结束页：　

文献类型：Article

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摘要："Objective. To explore the effects of pramipexole combined with nerve growth factor (NGF) on cognitive impairment and urinary Alzheimer-associated neural thread protein (AD7c-NTP) expression in patients with Parkinson's disease (PD). Methods. Fifty patients with PD treated in our hospital from February 2020 to April 2021 were enrolled. The patients were arbitrarily assigned into control group and study group. The former was treated with pramipexole, and the latter was treated with pramipexole combined with NGF. The efficacy, cognitive function, serum inflammatory factors, cortisol levels, serum macrophage migration inhibitory factor (MIF), brain-derived neurotrophic factor (BDNF), urine AD7c-NTP levels, and the incidence of adverse reactions were compared. Results. First of all, the effective rate in the study group was higher compared to the control group (P < 0.05). After treatment, the cognitive function was enhanced, and the scores of Montreal cognitive assessment (MoCA) in the study group were higher compared to the control group (P < 0.05). The levels of serum IL-6, CRP, and TNF-alpha decreased after treatment, and the levels of serum IL-6, CRP, and TNF-alpha in the study group were remarkably lower compared to the control group (P < 0.05). In addition, the levels of serum DA, NE, and 5-HT increased after treatment, and the levels of serum DA, NE, and 5-HT in the study group were remarkably higher compared to the control group (P < 0.05). Then, the levels of serum MIF and urine AD7c-NTP decreased and BDNF increased after treatment, and the level of BDNF in the study group was higher compared to the control group, while the levels of serum MIF and urine AD7c-NTP in the study group were lower compared to the control group (P < 0.05). Finally, the adverse reactions were compared. The incidence of adverse reactions in the study group was lower compared to the control group, and the difference exhibited not statistically significant (16.00% vs. 24.00%, P > 0.05). Conclusion.Pramipexole combined with NGF therapy not only can effectively strengthen the cognitive impairment of patients with PD and promote clinical efficacy and high safety but also can inhibit inflammatory state, regulate brain neurotransmitters, and reduce urinary AD7c-NTP levels."

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