The roles of ADAMDEC1 in trophoblast differentiation during normal pregnancy and preeclampsia

作者全名："Li, Zhuo-Hang; Li, Xia; Li, Fang-Fang; Wu, Zhi-Hong; Xie, You-Long; Zhang, Shuang; Chen, Xue-Mei; Wang, Ying-Xiong; Ding, Yu-Bin; Liu, Tai-Hang"

作者地址："[Li, Zhuo-Hang; Li, Xia; Li, Fang-Fang; Wu, Zhi-Hong; Xie, You-Long; Zhang, Shuang; Chen, Xue-Mei; Wang, Ying-Xiong; Ding, Yu-Bin; Liu, Tai-Hang] Chongqing Med Univ, Joint Int Res Lab Reprod & Dev, Chongqing, Peoples R China; [Liu, Tai-Hang] Chongqing Med Univ, Sch Basic Med, Dept Bioinformat, Chongqing, Peoples R China"

通信作者："Wang, YX; Ding, YB; Liu, TH (通讯作者)，Chongqing Med Univ, Joint Int Res Lab Reprod & Dev, Chongqing, Peoples R China.; Liu, TH (通讯作者)，Chongqing Med Univ, Sch Basic Med, Dept Bioinformat, Chongqing, Peoples R China."

来源：MOLECULAR HUMAN REPRODUCTION

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000797141500001

JCR分区：Q1

影响因子：4

年份：2022

卷号：28

期号：5

开始页：　

结束页：　

文献类型：Article

关键词：placenta; trophoblast; cell differentiation; ADAMDEC1; preeclampsia

摘要："Human cytotrophoblast (CTB) differentiation into syncytiotrophoblast (STB) is essential for placental formation and function. Understanding the molecular mechanisms involved in trophoblast differentiation is necessary as it would help in the development of novel therapeutic agents to treat placentation-mediated pregnancy complications. In this study, we found a common upregulated gene, ADAM-like Decysin-1 (ADAMDEC1), from five published microarray and RNA-sequencing datasets. Interference to ADAMDEC1 impaired forskolin-induced BeWo cells differentiation, while ADAMDEC1 overexpression promoted BeWo cells and 3D JEG-3 spheroids differentiation. Interestingly, ADAMDEC1 may inhibit Thrombospondin 1 rather than E-cadherin to trigger the activation of the cAMP signal pathway during CTB differentiation into STB. More importantly, a decreasing in ADAMDEC1 might be involved in the development of preeclampsia. Therefore, ADAMDEC1 is expected to become a new target for prediction of and intervention in placenta-derived pregnancy diseases."

基金机构："National Natural Science Foundation of China [81801458, 81671493, 82171664]; National Key Research and Development Program of China [2018YFC1004400]"

基金资助正文："This work was funded by the National Natural Science Foundation of China (grant numbers 81801458, 81671493 and 82171664) and the National Key Research and Development Program of China (grant number 2018YFC1004400)."