Age and sex specific reference intervals of 13 hematological analytes in Chinese children and adolescents aged from 28 days up to 20 years: the PRINCE study

作者全名："Song, Wenqi; Yan, Ruohua; Peng, Mingting; Jiang, Hong; Li, Guixia; Cao, Sancheng; Jiang, Yongmei; Guo, Zhenxin; Chen, Dapeng; Yang, Hongling; Xu, Jin; Chang, Yong; Xiang, Yun; Zhao, Min; Li, Chenbin; Shen, Ying; Jin, Fang; Li, Qiliang; Wang, Yan; Peng, Yaguang; Hu, Lixin; Liu, Ying; Zhang, Xiaofei; Chen, Wenxiang; Peng, Xiaoxia; Ni, Xin"

作者地址："[Peng, Mingting; Li, Chenbin; Chen, Wenxiang] Natl Ctr Clin Labs NCCL, 1 Dahua Rd, Beijing 100730, Peoples R China; [Song, Wenqi; Yan, Ruohua; Shen, Ying; Jin, Fang; Li, Qiliang; Wang, Yan; Peng, Yaguang; Hu, Lixin; Liu, Ying; Zhang, Xiaofei; Peng, Xiaoxia; Ni, Xin] Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, 56 Nanlishi Rd, Beijing 100045, Peoples R China; [Jiang, Hong; Zhao, Min] China Med Univ, Hosp 1, Shenyang, Liaoning, Peoples R China; [Li, Guixia] Childrens Hosp Hebei Prov, Shijiazhuang, Hebei, Peoples R China; [Cao, Sancheng] Xian Childrens Hosp, Xian, Shaanxi, Peoples R China; [Jiang, Yongmei] Sichuan Univ, West China Univ Hosp 2, Chengdu, Sichuan, Peoples R China; [Guo, Zhenxin] Zhengzhou Childrens Hosp, Henan Childrens Hosp, Zhengzhou, Henan, Peoples R China; [Chen, Dapeng] Chongqing Med Univ, Childrens Hosp, Chongqing, Peoples R China; [Yang, Hongling] Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Guangzhou, Guangdong, Peoples R China; [Xu, Jin] Fudan Univ, Childrens Hosp, Shanghai, Peoples R China; [Chang, Yong] Nanjing Med Univ, Childrens Hosp, Nanjing, Jiangsu, Peoples R China; [Xiang, Yun] Wuhan Women & Children Med Care Ctr, Wuhan, Hubei, Peoples R China"

通信作者："Chen, WX (通讯作者)，Natl Ctr Clin Labs NCCL, 1 Dahua Rd, Beijing 100730, Peoples R China.; Peng, XX; Ni, X (通讯作者)，Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, 56 Nanlishi Rd, Beijing 100045, Peoples R China."

来源：CLINICAL CHEMISTRY AND LABORATORY MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000799109800001

JCR分区：Q1

影响因子：6.8

年份：2022

卷号：60

期号：8

开始页：1250

结束页：1260

文献类型：Article

关键词：China; complete blood cell count; hematology; pediatric; reference interval

摘要："Objectives Pediatric Reference Intervals in China (PRINCE) is a nationwide initiative that aims to establish and validate harmonized reference intervals (RIs) for Chinese children and adolescents, in which 15,150 healthy volunteers aged up to 20 years were recruited from 11 centers to establish RIs and 7,557 children and adolescents were enrolled from 21 centers to validate RIs. Methods The complete blood cell counts (CBC) of venous whole blood were measured by hematology analyzers through Sysmex systems in different centers. Age- and sex-specific RIs were calculated according to the guidelines. Results Unlike adults with certain levels of analyte concentrations, hematological parameters of children changed through growth and development. Red blood cell counts, hemoglobin, and hematocrit increased with age, and revealed higher concentrations in boys than girls after puberty. White blood cell counts and platelet counts showed significant higher levels than adults before 2 years of age, and then gradually decreased without distinct sex differences. In addition, lymphocyte counts decreased with age while neutrophil counts showed an opposite trend. The lower and upper limits of pediatric RIs of CBC were different from those of adults. Conclusions The validation of RIs indicated that the PRINCE study provided a version of RIs suitable for most of regions in China. This first harmonized pediatric RIs of CBC across China provided a robust database to understand the dynamic changes of hematologic parameters from birth to adolescence, and will contribute to clinical diagnosis and prognosis evaluation for pediatric patients as well."

基金机构："Medical Hospital Authority, National Health Commission of the People's Republic of China [2017374]"

基金资助正文："This study was supported by the grant from the Medical Hospital Authority, National Health Commission of the People's Republic of China (No. 2017374)."