"Childhood trauma and the plasma levels of IL-6, TNF-alpha are risk factors for major depressive disorder and schizophrenia in adolescents: A cross-sectional and case-control study"

作者全名：Yi Li; Tang Jinxiang; Yang Shu; Peng Yadong; Liu Ying; Yuan Meng; Zhang Ping; Hou Xiao; Fu Yixiao

作者地址："[Yi Li; Tang Jinxiang; Yang Shu; Peng Yadong; Liu Ying; Yuan Meng; Fu Yixiao] Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Tang Jinxiang] Bishan Hosp Chongqing, Sleep & Psychol Ctr, Chongqing 402760, Peoples R China; [Peng Yadong; Liu Ying] Chongqing Hlth Ctr Women & Children, Dept Psychol, Chongqing 401147, Peoples R China; [Hou Xiao] Chongqing Med & Pharmaceut Coll, Dept Clin Med, Chongqing 401331, Peoples R China; [Zhang Ping] Sichuan Int Study Univ, Dept English, Chongqing 400000, Peoples R China"

通信作者："Fu, YX (通讯作者)，Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing 400016, Peoples R China.; Hou, X (通讯作者)，Chongqing Med & Pharmaceut Coll, Dept Clin Med, Chongqing 401331, Peoples R China."

来源：JOURNAL OF AFFECTIVE DISORDERS

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:000799610100023

JCR分区：Q1

影响因子：6.6

年份：2022

卷号：305

期号：　

开始页：227

结束页：232

文献类型：Article

关键词："Major depressive disorder; Schizophrenia; IL-6, TNF-alpha; Childhood trauma"

摘要："Background: It has been reported that childhood trauma and inflammation are associated with major depressive disorder (MDD) and schizophrenia (SZ), but previous researches were almost aimed at adults. The aim of the present research is to observe the alteration of peripheral interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF alpha) in adolescents (12-20 years) with MDD and SZ, to investigate the impact of childhood abuse in early-onset MDD and SZ, and to furtherly explore the correlation between childhood maltreatment and plasma IL-6, TNF alpha levels. Subjects and Methods: Enzyme-linked immunosorbent assay (ELISA) is applied to obtain the plasma concentrations of IL-6 and TNF-alpha in 55 patients with MDD, 51 patients with SZ and 47 healthy minors. The short form of the Childhood Trauma Questionnaire (CTQ-SF) is used to assess the severity of early trauma. Results: Plasma IL-6 and TNF-alpha levels are significantly elevated in patients with early-onset MDD and SZ compared with healthy subjects (p <0.01), whose results display that the correlation between IL-6 and TNF-alpha is significantly positive (gamma=0.787, p <0.01) in all participants. Compared with the healthy adolescents, patients with MDD and SZ show more serious childhood trauma, and the plasma IL-6, TNF-alpha concentrations are closely related to childhood maltreatment. Conclusions: Early trauma and peripheral inflammatory response play an important role in the pathophysiology of early-onset MDD or SZ. The current findings provide effective targets for the prevention, diagnosis, and treatment of major depressive disorder and schizophrenia in adolescents."

基金机构："Chongqing Science and Technology Commission [cstc2018jcy-jAX0252, 2019MSXM045]; Chongqing Municipal Education Commission [2017SKG017]; Chongqing Health Commission"

基金资助正文："This work was supported by the following organizations and pro-jects: Chongqing Science and Technology Commission (cstc2018jcy-jAX0252) , Chongqing Municipal Education Commission (2017SKG017) , Chongqing Health Commission and Chongqing Science and Technology Commission (2019MSXM045) , the authors would like to thank the support of these organizations."