"The Impact of Active Screening and Management on COVID-19 in Plateau Region of Sichuan, China"
作者全名："Lu, Jia-jie; Jiang, Guo-guo; He, Xiang; Xu, Kai-ju; Yang, Hong; Shi, Rui; Chen, Ying; Tan, Yu-yao; Bai, Lang; Tang, Hong; Li, Guo-ping"
作者地址："[Lu, Jia-jie; Shi, Rui; Bai, Lang; Tang, Hong] Sichuan Univ, Ctr Infect Dis, West China Hosp, Chengdu, Peoples R China; [Jiang, Guo-guo] Chengdu Second People Hosp, Dept Hosp Infect Management, Chengdu, Peoples R China; [He, Xiang; Li, Guo-ping] Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Chengdu Inst Resp Hlth, Lab Allergy & Precis Med,Affiliated Hosp, Chengdu, Peoples R China; [He, Xiang; Li, Guo-ping] ChongQing Med Univ, Chengdu Peoples Hosp Branch 3, Dept Pulm & Crit Care Med, Natl Clin Res Ctr Resp Dis,Affiliated Hosp, Chengdu, Peoples R China; [Xu, Kai-ju] Sichuan Acad Med Sci, Dept Infect Dis, Chengdu, Peoples R China; [Xu, Kai-ju] Sichuan Prov Peoples Hosp, Chengdu, Peoples R China; [Yang, Hong; Shi, Rui; Chen, Ying; Tan, Yu-yao] Peoples Hosp Ganzi Tibetan Autonomous Prefecture, Kangding, Ganzi, Peoples R China"
通信作者："Tang, H (通讯作者)，Sichuan Univ, Ctr Infect Dis, West China Hosp, Chengdu, Peoples R China.; Li, GP (通讯作者)，Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Chengdu Inst Resp Hlth, Lab Allergy & Precis Med,Affiliated Hosp, Chengdu, Peoples R China.; Li, GP (通讯作者)，ChongQing Med Univ, Chengdu Peoples Hosp Branch 3, Dept Pulm & Crit Care Med, Natl Clin Res Ctr Resp Dis,Affiliated Hosp, Chengdu, Peoples R China."
来源：FRONTIERS IN MEDICINE
ESI学科分类：CLINICAL MEDICINE
WOS号：WOS:000800062300001
JCR分区：Q1
影响因子：3.9
年份：2022
卷号：9
期号：
开始页：
结束页：
文献类型：Article
关键词：COVID-19; hypoxic plateau area; clinical characteristics; control strategies; severe pneumonia
摘要："BackgroundIn December 2019, the cases of pneumonia of unknown etiology emerged in Wuhan, China, and rapidly spread throughout the country. The disease was later designated by the World Health Organization (WHO) as Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS CoV-2). Few studies have assessed the clinical characteristics of COVID-19 and control strategies used to mitigate disease spread in high-altitude plateau regions of China. Study ObjectiveTo assess the impact of real-world strategies to control COVID-19 spread in remote plateau regions. MethodsA retrospective study was performed to assess the epidemiology of COVID-19 and strategies used to control disease spread in the high-altitude plateau of Sichuan, China from 24 January 2020 to 19 March 2020. ResultsCOVID-19 spread and outbreaks in Sichuan were attributed to mass gatherings. A total of 70 patients and 20 asymptomatic individuals were found in the hypoxic plateau region of Sichuan. Twelve patients were admitted after the onset of symptoms, while 58 patients and 20 asymptomatic individuals were found by active screening. The symptomatic patients included those with uncomplicated illness (16/70, 22.9%), mild pneumonia (44/70, 62.9%), and severe pneumonia (10/70, 14.3%). Most patients in the study area showed relatively mild and atypical symptoms such as low or no fever and dyspnea. The incidence of severe pneumonia, fever, dyspnea, and interstitial abnormalities identified by chest CT were all significantly lower in screened patients than those admitted after symptom onset (P < 0.05). Severe pneumonia was noted in patients with chronic conditions like hypertension, diabetes etc. as compared to less severe pneumonia in healthy subjects (P <0.05). No patients died and all were eventually discharged. ConclusionMass gatherings increased risk of spread of SARS-CoV-2 responsible for COVID-19. Active screening and early management have collectively contributed to reduced incidence of severe pneumonia and satisfactory prognoses of infections with COVID-19 in this hypoxic plateau region."
基金机构：2019-nCoV tackling project of Chengdu Science and Technology Bureau [2020-YF05-00003-SN]
基金资助正文：Funding This work was supported by 2019-nCoV tackling project of Chengdu Science and Technology Bureau (2020-YF05-00003-SN).
