Mechanical Cues Regulate Histone Modifications and Cell Behavior

作者全名："Hu, Buwei; Zhou, Dandan; Wang, Haoming; Hu, Ning; Zhao, Weikang"

作者地址："[Hu, Buwei; Hu, Ning; Zhao, Weikang] Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 1, Chongqing, Peoples R China; [Hu, Buwei] Westlake Univ, Sch Life Sci, Zhejiang Prov Lab Life Sci & Biomed, Hangzhou 310024, Zhejiang, Peoples R China; [Zhou, Dandan] Peoples Hosp Jiulongpo Dist, Dept Gastroenterol, Chongqing 400050, Peoples R China; [Wang, Haoming] Chongqing Univ, Three Gorges Hosp, Dept Orthoped, Chongqing 404100, Peoples R China"

通信作者："Hu, N; Zhao, WK (通讯作者)，Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 1, Chongqing, Peoples R China.; Wang, HM (通讯作者)，Chongqing Univ, Three Gorges Hosp, Dept Orthoped, Chongqing 404100, Peoples R China."

来源：STEM CELLS INTERNATIONAL

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000800251100001

JCR分区：Q3

影响因子：4.3

年份：2022

卷号：2022

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：　

摘要："Change of biophysical factors in tissue microenvironment is an important step in a chronic disease development process. A mechanical and biochemical factor from cell living microniche can regulate cell epigenetic decoration and, therefore, further induce change of gene expression. In this review, we will emphasize the mechanism that biophysical microenvironment manipulates cell behavior including gene expression and protein decoration, through modifying histone amino acid residue modification. The influence given by different mechanical forces, including mechanical stretch, substrate surface stiffness, and shear stress, on cell fate and behavior during chronic disease development including tumorigenesis will also be teased out. Overall, the recent work summarized in this review culminates on the hypothesis that a mechanical factor stimulates the modification on histone which could facilitate disease detection and potential therapeutic target."

基金机构："Natural Science Foundation of China [82072443, 82102571]; Natural Science Foundation of Chongqing, China [cstc2020jscx-msxmX0094, cstc2021jcyj-msxmX0569]; Science and Health Foundation of Chongqing [2019ZDXM014]"

基金资助正文："AcknowledgmentsThis work was supported by grants from the Natural Science Foundation of China (Nos. 82072443 and 82102571) the Natural Science Foundation of Chongqing, China (Nos. cstc2020jscx-msxmX0094 and cstc2021jcyj-msxmX0569) and Science and Health Foundation of Chongqing(2019ZDXM014)."