Impaired glucose metabolism underlies articular cartilage degeneration in osteoarthritis

作者全名："Li, Ke; Ji, Xing; Seeley, Rebecca; Lee, Wen-Chih; Shi, Yu; Song, Fangfang; Liao, Xueyang; Song, Chao; Huang, Xiaobin; Rux, Danielle; Cao, Ju; Luo, Xiaoji; Anderson, Steven M.; Huang, Wei; Long, Fanxin"

作者地址："[Li, Ke; Luo, Xiaoji; Huang, Wei] Chongqing Med Univ, Dept Orthopaed Surg, Affiliated Hosp 1, Chongqing, Peoples R China; [Li, Ke; Ji, Xing; Seeley, Rebecca; Lee, Wen-Chih; Shi, Yu; Song, Fangfang; Liao, Xueyang; Song, Chao; Huang, Xiaobin; Rux, Danielle; Long, Fanxin] Childrens Hosp Philadelphia, Dept Surg, Translat Res Program Pediat Orthoped, Philadelphia, PA 19104 USA; [Cao, Ju] Chongqing Med Univ, Dept Lab Med, Affiliated Hosp 1, Chongqing, Peoples R China; [Anderson, Steven M.] Univ Colorado, Sch Med, Dept Pathol, Denver, CO 80262 USA"

通信作者："Long, FX (通讯作者)，Childrens Hosp Philadelphia, Abramson Res Ctr, Suite 902,3615 Civ Ctr Blvd, Philadelphia, PA 19104 USA."

来源：FASEB JOURNAL

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000800641200004

JCR分区：Q1

影响因子：4.8

年份：2022

卷号：36

期号：6

开始页：　

结束页：　

文献类型：Article

关键词：articular cartilage; diabetes; Glut1; glycolysis; osteoarthritis

摘要："Osteoarthritis (OA) is the leading joint disease characterized by cartilage destruction and loss of mobility. Accumulating evidence indicates that the incidence and severity of OA increases with diabetes, implicating systemic glucose metabolism in joint health. However, a definitive link between cellular metabolism in articular cartilage and OA pathogenesis is not yet established. Here, we report that in mice surgically induced to develop knee OA through destabilization of medial meniscus (DMM), expression of the main glucose transporter Glut1 is notably reduced in joint cartilage. Inducible deletion of Glut1 specifically in the Prg4-expressing articular cartilage accelerates cartilage loss in DMM-induced OA. Conversely, forced expression of Glut1 protects against cartilage destruction following DMM. Moreover, in mice with type I diabetes, both Glut1 expression and the rate of glycolysis are diminished in the articular cartilage, and the diabetic mice exhibit more severe cartilage destruction than their nondiabetic counterparts following DMM. The results provide proof of concept that boosting glucose metabolism in articular chondrocytes may ameliorate cartilage degeneration in OA."

基金机构：China Scholarship Council (CSC) [201908500129]; National Natural Science Foundation of China (NSFC) [81902293]

基金资助正文："China Scholarship Council (CSC), Grant/Award Number: 201908500129; National Natural Science Foundation of China (NSFC), Grant/Award Number: 81902293"