Assessment of Customized Alveolar Bone Augmentation Using Titanium Scaffolds vs Polyetheretherketone (PEEK) Scaffolds: A Comparative Study Based on 3D Printing Technology

作者全名："Li, Linzhi; Gao, Hui; Wang, Chunjuan; Ji, Ping; Huang, Yuanding; Wang, Chao"

作者地址："[Li, Linzhi; Gao, Hui; Wang, Chunjuan; Ji, Ping; Huang, Yuanding; Wang, Chao] Chongqing Med Univ, Stomatol Hosp, Chongqing 401147, Peoples R China; [Li, Linzhi; Gao, Hui; Wang, Chunjuan; Ji, Ping; Huang, Yuanding] Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 401147, Peoples R China; [Wang, Chao] Beihang Univ, Key Lab Biomech & Mech, Minist Educ, Beijing Adv Innovat Ctr Biomed Engn,Sch Biol Sci, Beijing 100083, Peoples R China"

通信作者："Huang, YD; Wang, C (通讯作者)，Chongqing Med Univ, Stomatol Hosp, Chongqing 401147, Peoples R China.; Huang, YD (通讯作者)，Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 401147, Peoples R China.; Wang, C (通讯作者)，Beihang Univ, Key Lab Biomech & Mech, Minist Educ, Beijing Adv Innovat Ctr Biomed Engn,Sch Biol Sci, Beijing 100083, Peoples R China."

来源：ACS BIOMATERIALS SCIENCE & ENGINEERING

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000800651400024

JCR分区：Q2

影响因子：5.8

年份：2022

卷号：8

期号：5

开始页：2028

结束页：2039

文献类型：Article

关键词：patient-specific polyetheretherketone scaffold; customized alveolar bone augmentation; patient-specific titanium scaffold; finite element analysis; additive manufacturing technology

摘要："Customized alveolar bone augmentation provides sufficientand precisely regenerated bone tissue for subsequent dental implantplacement. Although some clinical cases have confirmed the successful useof the patient-specific polyetheretherketone (PEEK) scaffolds, thebiomechanical property and osteogenic performance of the patient-specificPEEK scaffolds remain unclear. The objectives of this study were (1) toevaluate the space maintenance capacity and osteogenic performance ofthe patient-specificPEEKscaffolds for customized alveolar boneaugmentation and (2) to compare the biomechanical properties ofthree-dimensionally printed titanium scaffolds and PEEK scaffolds. Bothtitanium scaffolds and PEEK scaffolds were designed and manufactured viaadditive manufacturing technology combined with computer-aided design(CAD). In three-point bending tests, the bending strength of the PEEKscaffold was about 1/3 that of the titanium scaffold. Accordingly, the equivalent strain value of the internal bone graft beneath thePEEK scaffold was about 3 times that beneath the titanium scaffold infinite element analysis, but the maximum deformations of bothscaffolds were less than 0.05 mm. Meanwhile, in in vivo experiments, it is demonstrated that both scaffolds have similar spacemaintenance capacity and bone ingrowth efficiency. In conclusion, patient-specific PEEK scaffolds showed significantly lowerbiomechanical strength but comparable space maintenance and osteogenic properties to the titanium counterpart. Compared withtraditional guided bone regeneration (GBR) surgery, both patient-specific PEEK and titanium scaffolds can achieve excellentosteogenic space maintenance ability. This study provides a preliminary basis for the clinical translation of the nonmetallic barriermembrane in customized alveolar bone augmentation."

基金机构："National Natural Science Foundation of China [12072055, 11872135, 12172034, U20A20390]; Natural Science Foundation of Beijing [L212063]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (Grant Nos. 12072055, 11872135, 12172034, and U20A20390) and the Natural Science Foundation of Beijing (Grant No. L212063). The authors gratefully acknowledge Changchun Dentec Dental Materials Co., Ltd., Jilin, China and Dr. Pengtao Yan for providing them with PEEK material, Reborn Medical Technology Co., Ltd., Shanghai, China and Ms. Jingping Peng for the manufacturing of titanium scaffolds (mesh), Chongqing Zotion Dentistry Technology Co., Ltd., Chongqing, China and Mr. Yuanwu Wang for the manufacturing of patient-specific PEEK scaffolds, and Ruisheng Biological Technology Co., Ltd., Shanxi, China for the calcined bovine bone grafting material and collagen pericardium membrane."