Molecular epidemiology of human Borna disease virus 1 infection revisited

作者全名："Bode, Liv; Guo, Yujie; Xie, Peng"

作者地址："[Bode, Liv] Bornavirus Workgrp, D-14163 Berlin, Germany; [Guo, Yujie] Chongqing Med Univ, Yongchuan Hosp, Dept Neurol, Chongqing, Peoples R China; [Guo, Yujie; Xie, Peng] Chongqing Med Univ, NHC Key Lab Diag & Treatment Brain Funct Dis, Affiliated Hosp 1, Chongqing, Peoples R China; [Xie, Peng] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China"

通信作者："Bode, L (通讯作者)，Bornavirus Workgrp, D-14163 Berlin, Germany."

来源：EMERGING MICROBES & INFECTIONS

ESI学科分类：MICROBIOLOGY

WOS号：WOS:000800952800001

JCR分区：Q1

影响因子：13.2

年份：2022

卷号：11

期号：1

开始页：1335

结束页：1338

文献类型：Editorial Material

关键词：Borna disease virus 1; BoDV-1; human complete BoDV-1 genomes; human and shrew amino acid BoDV-1 mutations; epidemiological concepts

摘要："Borna disease virus 1 (BoDV-1) strains attracted public interest by recently reported rare fatal encephalitis cases in Germany. Previously, human BoDV-1 infection was suggested to contribute to psychiatric diseases. Clinical outcomes (encephalitis vs. psychiatric disease) and epidemiology (zoonotic vs. human-to-human transmission) are still controversial. Here, phylogenetic analyses of 18 human and 4 laboratory strains revealed close genomic homologies both in distant geographical regions, and different clinical entities. Single unique amino acid mutations substantiated the authenticity of human strains. No matching was found with those of shrew strains in the same cluster 4, arguing against zoonosis. Opposite epidemiology concepts should be equally considered."

基金机构：National Key Research and Development Program of China [2017YFA0505700]; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [2019PT320002]; National Natural Science Foundation Project of China [81820108015]; Special Grant for Chongqing postdoctoral researcher research project [2010010004897023]; Postdoctoral Science Foundation of Chongqing [cstc2021jcyj-bsh0015]

基金资助正文："National Key Research and Development Program of China [grant number Grant no.2017YFA0505700], the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [grant number 2019PT320002], the National Natural Science Foundation Project of China [grant number 81820108015], Special Grant for Chongqing postdoctoral researcher research project [grant number 2010010004897023], Postdoctoral Science Foundation of Chongqing [grant number cstc2021jcyj-bsh0015]."