Synovial Fluid Interleukin Levels Cannot Distinguish between Prosthetic Joint Infection and Active Rheumatoid Arthritis after Hip or Knee Arthroplasty

作者全名："Qin, Leilei; Du, Chengcheng; Yang, Jianye; Wang, Hai; Su, Xudong; Wei, Li; Zhao, Chen; Chen, Cheng; Chen, Hong; Hu, Ning; Huang, Wei"

作者地址："[Qin, Leilei; Du, Chengcheng; Yang, Jianye; Wang, Hai; Su, Xudong; Wei, Li; Zhao, Chen; Chen, Cheng; Chen, Hong; Hu, Ning; Huang, Wei] Chongqing Med Univ, Dept Orthopaed, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Qin, Leilei; Du, Chengcheng; Yang, Jianye; Wang, Hai; Su, Xudong; Wei, Li; Zhao, Chen; Chen, Cheng; Chen, Hong; Hu, Ning; Huang, Wei] Chongqing Med Univ, Orthoped Lab, Chongqing 400016, Peoples R China"

通信作者："Hu, N; Huang, W (通讯作者)，Chongqing Med Univ, Dept Orthopaed, Affiliated Hosp 1, Chongqing 400016, Peoples R China.; Hu, N; Huang, W (通讯作者)，Chongqing Med Univ, Orthoped Lab, Chongqing 400016, Peoples R China."

来源：DIAGNOSTICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000801409100001

JCR分区：Q1

影响因子：3.6

年份：2022

卷号：12

期号：5

开始页：　

结束页：　

文献类型：Article

关键词：prosthetic joint infection; synovial fluid; inflammatory marker; interleukins; rheumatoid arthritis

摘要："Inflammatory arthritis affects the level of synovial inflammatory factors, which makes it more difficult to diagnose prosthetic joint infection (PJI) patients with inflammatory arthritis. The aim of this study was to analyze synovial interleukin levels to distinguish between PJI and active rheumatoid arthritis (RA) after a hip or knee arthroplasty. From September 2019 to September 2021, we prospectively enrolled patients with joint pain after arthroplasty due to aseptic prosthesis loosening (n = 39), acute RA (n = 26), and PJI (n = 37). Synovial fluid from the affected joint is obtained and tested with a standard enzyme-linked immunosorbent assay. Receiver operating characteristic curve (ROC) was analyzed for each biomarker. Interleukin (IL)-1 beta, IL-6, and IL-8 showed promising value in differentiating of aseptic loosening from PJI, with areas under the curves (AUCs) of 0.9590, 0.9506, and 0.9616, respectively. Synovial IL-1 beta, IL-6, and IL-8 showed limited value in distinguishing between PJI and acute episodes of RA after arthroplasty, with AUCs of 0.7507, 0.7069, and 0.7034, respectively. Interleukins showed satisfactory efficacy in differentiating aseptic loosening from PJI. However, when pain after arthroplasty results from an acute episode of RA, current synovial interleukin levels do not accurately rule out the presence of PJI."

基金机构："National Natural Science Foundation of China [82072443, 81972069]"

基金资助正文：This work was supported by the National Natural Science Foundation of China (82072443 (Ning Hu) and 81972069 (Wei Huang)). No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.