Pu-erh Tea Restored Circadian Rhythm Disruption by Regulating Tryptophan Metabolism

作者全名："Hu, Shanshan; Luo, Liyong; Bian, Xintong; Liu, Rui Hai; Zhao, Sibo; Chen, Yu; Sun, Kang; Jiang, Jielin; Liu, Zhonghua; Zeng, Liang"

作者地址："[Hu, Shanshan; Luo, Liyong; Zhao, Sibo; Chen, Yu; Sun, Kang] Southwest Univ, Coll Food Sci, Chongqing 400715, Peoples R China; [Bian, Xintong] Chongqing Med Univ, Key Lab Clin Lab Diagnost, Minist Educ, Coll Lab Med, Chongqing 400016, Peoples R China; [Liu, Rui Hai] Cornell Univ, Dept Food Sci, Ithaca, NY 14850 USA; [Jiang, Jielin] Menghai Tea Factory, TAETEA Grp, Shanghai 666200, Yunnan, Peoples R China; [Liu, Zhonghua] Hunan Agr Univ, Minist Educ Tea Sci, Key Lab, Changsha 410128, Peoples R China; [Zeng, Liang] Southwest Univ, Coll Food Sci, Chongqing 400715, Peoples R China; [Zeng, Liang] Chongqing Southwest Univ, Chongqing Key Lab Special Food Cobuilt Sichuan &, Chongqing 400715, Peoples R China"

通信作者："Liu, ZH (通讯作者)，Hunan Agr Univ, Minist Educ Tea Sci, Key Lab, Changsha 410128, Peoples R China.; Zeng, L (通讯作者)，Southwest Univ, Coll Food Sci, Chongqing 400715, Peoples R China.; Zeng, L (通讯作者)，Chongqing Southwest Univ, Chongqing Key Lab Special Food Cobuilt Sichuan &, Chongqing 400715, Peoples R China."

来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:000802050800012

JCR分区：Q1

影响因子：6.1

年份：2022

卷号：70

期号：18

开始页：5610

结束页：5623

文献类型：Article

关键词：circadian rhythm disruption; Pu-erh tea; gut-liver-brain axis; gut microbiota; tryptophan metabolism

摘要："Pu-erh tea is a healthy beverage rich in phytochemicals, and its effect on the risk of inducing circadian rhythm disorders (CRD) is unclear. In this study, healthy mice were given water or 0.25% (w/v) Pu-erh tea for 7 weeks, followed by a 40 day disruption of the light/dark cycle. CRD caused dysregulation of neurotransmitter secretion and clock gene oscillations, intestinal inflammation, and disruption of intestinal microbes and metabolites. Pu-erh tea boosted the indole and 5-hydroxytryptamine pathways of tryptophan metabolism via the gut-liver-brain axis. Furthermore, its metabolites (e.g., IAA, Indole, 5-HT) enhanced hepatic glycolipid metabolism and down-regulated intestinal oxidative stress by improving the brain hormone release. Tryptophan metabolites and bile acids also promoted liver lipid metabolism and inhibited intestinal inflammation (MyD88/NF-Kappa B) via the enterohepatic circulation. Collectively, 0.25% (w/v) Pu-erh tea has the potential to prevent CRD by promoting indole and 5-HT pathways of tryptophan metabolism and signaling interactions in the gut-liver-brain axis."

基金机构："Chongqing Technology Innovation and Application Demonstration Project - Germplasm Creation Research Program of Southwest University, Chongqing Technology Innovation and Application Development Project [cstc2020jscx-tpyzxX0009, cstc2020jscx-tpyzxX0012]; Chongqing Science and Technology Bureau [cstc2019jscx-dxwtBX0030]"

基金资助正文："Thanks to all the members of Liang Laboratory for participating in the mouse experiment of this study. This work was supported by the Chongqing Technology Innovation and Application Demonstration Project (cstc2020jscx-tpyzxX0009), supported by the Germplasm Creation Research Program of Southwest University, Chongqing Technology Innovation and Application Development Project [cstc2020jscx-tpyzxX0012], and Chongqing Science and Technology Bureau [cstc2019jscx-dxwtBX0030]."