Self-Confirming Magnetosomes for Tumor-Targeted T-1/T-2 Dual-Mode MRI and MRI-Guided Photothermal Therapy

作者全名："Jiang, Gexuan; Fan, Di; Tian, Jiesheng; Xiang, Zhichu; Fang, Qiaojun"

作者地址："[Jiang, Gexuan; Fan, Di; Xiang, Zhichu; Fang, Qiaojun] Chinese Acad Sci, Lab Theoret & Computat Nanosci, CAS Key Lab Nanophoton Mat & Devices,Natl Ctr Nan, CAS Ctr Excellence Nanosci,Beijing Key Lab Ambien, Beijing 100190, Peoples R China; [Jiang, Gexuan; Fang, Qiaojun] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Tian, Jiesheng] China Agr Univ, State Key Labs Agrobiotechnol, Beijing 100193, Peoples R China; [Tian, Jiesheng] China Agr Univ, Coll Biol Sci, Beijing 100193, Peoples R China; [Xiang, Zhichu] Chongqing Med Univ, Coll Lab Med, Key Lab Clin Lab Diagnost, Minist Educ, Chongqing, Peoples R China; [Fang, Qiaojun] Sino Danish Ctr Educ & Res, Beijing 101408, Peoples R China"

通信作者："Xiang, ZC; Fang, QJ (通讯作者)，Chinese Acad Sci, Lab Theoret & Computat Nanosci, CAS Key Lab Nanophoton Mat & Devices,Natl Ctr Nan, CAS Ctr Excellence Nanosci,Beijing Key Lab Ambien, Beijing 100190, Peoples R China.; Fang, QJ (通讯作者)，Univ Chinese Acad Sci, Beijing 100049, Peoples R China.; Xiang, ZC (通讯作者)，Chongqing Med Univ, Coll Lab Med, Key Lab Clin Lab Diagnost, Minist Educ, Chongqing, Peoples R China.; Fang, QJ (通讯作者)，Sino Danish Ctr Educ & Res, Beijing 101408, Peoples R China."

来源：ADVANCED HEALTHCARE MATERIALS

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000802236900001

JCR分区：Q1

影响因子：10

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：magnetosomes; Mn-doping; biosynthesis; dual-mode MRI; tumors; MRI; PTT

摘要："Nanomaterials as T-1/T-2 dual-mode magnetic resonance imaging (MRI) contrast agents have great potential in improving the accuracy of tumor diagnosis. Applications of such materials, however, are limited by the complicated chemical synthesis process and potential biosafety issues. In this study, the biosynthesis of manganese (Mn)-doped magnetosomes (MagMn) that not only can be used in T-1/T-2 dual-mode MR imaging with self-confirmation for tumor detection, but also improve the photothermal conversion efficiency for MRI-guided photothermal therapy (PTT) is reported. The MagMn nanoparticles (NPs) are naturally produced through the biomineralization of magnetotactic bacteria by doping Mn into the ferromagnetic iron oxide crystals. In vitro and in vivo studies demonstrated that targeting peptides functionalized MagMn enhanced both T-1 and T-2 MRI signals in tumor tissue and significantly inhibited tumor growth by the further MRI-guided PTT. It is envisioned that the biosynthesized multifunctional MagMn nanoplatform may serve as a potential theranostic agent for cancer diagnosis and treatment."

基金机构：Strategic Priority Research Program of the Chinese Academy of Sciences [XDB36000000]; National Natural Science Foundation [32027801]

基金资助正文："This study is supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDB36000000), and National Natural Science Foundation (32027801)."