Higher Cerebral Small Vessel Disease Burden in Patients With Small Intracerebral Hemorrhage

作者全名："Wang, Zi-Jie; Zhao, Rui; Hu, Xiao; Yang, Wen-Song; Deng, Lan; Lv, Xin-Ni; Li, Zuo-Qiao; Cheng, Jing; Pu, Ming-Jun; Tang, Zhou-Ping; Wu, Guo-Feng; Zhao, Li-Bo; Xie, Peng; Li, Qi"

作者地址："[Wang, Zi-Jie; Hu, Xiao; Yang, Wen-Song; Deng, Lan; Lv, Xin-Ni; Li, Zuo-Qiao; Cheng, Jing; Pu, Ming-Jun; Xie, Peng; Li, Qi] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China; [Zhao, Rui; Zhao, Li-Bo] Chongqing Med Univ, Dept Neurol, Yongchuan Hosp, Chongqing, Peoples R China; [Yang, Wen-Song; Xie, Peng; Li, Qi] Chongqing Med Univ, Key Lab Diag & Treatment Brain Funct Dis, Affiliated Hosp 1, Natl Hlth Commiss NHC, Chongqing, Peoples R China; [Tang, Zhou-Ping] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Neurol, Wuhan, Peoples R China; [Wu, Guo-Feng] Guizhou Med Univ, Emergency Dept, Affiliated Hosp, Guiyang, Peoples R China; [Li, Qi] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02115 USA"

通信作者："Li, Q (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China.; Li, Q (通讯作者)，Chongqing Med Univ, Key Lab Diag & Treatment Brain Funct Dis, Affiliated Hosp 1, Natl Hlth Commiss NHC, Chongqing, Peoples R China.; Li, Q (通讯作者)，Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02115 USA."

来源：FRONTIERS IN NEUROSCIENCE

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000803678300001

JCR分区：Q2

影响因子：4.3

年份：2022

卷号：16

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：intracerebral hemorrhage; cerebral small vessel disease; computed tomography; magnetic resonance imaging; neuroimaging; stroke

摘要："ObjectiveTo investigate the association between cerebral small vessel disease (SVD) and hematoma volume in primary intracerebral hemorrhage (ICH). MethodsPatients from a prospective ICH cohort were enrolled. Admission and follow-up CT scan within 72 h after onset were reviewed to calculate the final hematoma volume. We evaluated cortical superficial siderosis and the global SVD score, including white matter hyperintensities, lacunes, enlarged perivascular space, and cerebral microbleeds on MRI. We conducted the multivariate logistic regression analyses to explore the association between SVD markers and small ICH, as well as hematoma volume. Hematoma location was stratified into lobar and non-lobar for subgroup analysis. ResultsA total of 187 patients with primary ICH (mean age 62.4 +/- 13.4 years, 67.9% male) were enrolled. 94 (50.2%) patients had small ICH. The multivariate logistic regression analysis showed an association between global SVD score and small ICH [adjusted odds ratio (aOR) 1.27, 95% CI 1.03-1.57, p = 0.027] and a trend of higher global SVD score towards non-lobar small ICH (aOR 1.23, 95% CI 0.95-1.58, p = 0.122). In the multivariate linear regression analysis, global SVD score was inversely related to hematoma volume of all ICH (beta = -0.084, 95% CI -0.142 to -0.025, p = 0.005) and non-lobar ICH (beta = -0.112, 95% CI -0.186 to -0.037, p = 0.004). Lacune (beta = -0.245, 95% CI -0.487 to -0.004, p = 0.046) was associated with lower non-lobar ICH volume. ConclusionGlobal SVD score is associated with small ICH and inversely correlated with hematoma volume. This finding predominantly exists in non-lobar ICH."

基金机构："National Natural Science Foundation of China [82071337]; National Key R&D Program of China [2018YFC1312200, 2018YFC1312203]; Chongqing High-end Young Investigator Project [2019GDRC005]; Science and Technology Innovation Project of Chengdu-Chongqing Economic Circle [KJCXZD2020019]; Chongqing Innovation Support Program for Returned Overseas Chinese Scholars [cx2020002]"

基金资助正文："This study was supported by the National Natural Science Foundation of China (Grant No. 82071337), the National Key R&D Program of China (Grant Nos. 2018YFC1312200 and 2018YFC1312203), the Chongqing High-end Young Investigator Project (Grant No. 2019GDRC005), the Science and Technology Innovation Project of ""Chengdu-Chongqing Economic Circle"" (Grant No. KJCXZD2020019), and the Chongqing Innovation Support Program for Returned Overseas Chinese Scholars (Grant No. cx2020002)."