Cerebral Perfusion Patterns of Anxiety State in Patients With Pulmonary Nodules: A Study of Cerebral Blood Flow Based on Arterial Spin Labeling

作者全名："Wang, Xiao-Hui; Liu, Xiao-Fan; Ao, Min; Wang, Ting; He, Jinglan; Gu, Yue-Wen; Fan, Jing-Wen; Yang, Li; Yu, Renqiang; Guo, Shuliang"

作者地址："[Wang, Xiao-Hui; Ao, Min; Wang, Ting; Yang, Li; Guo, Shuliang] Chongqing Med Univ, Affiliated Hosp 1, Dept Pulm & Crit Care Med, Chongqing, Peoples R China; [Liu, Xiao-Fan] Shaanxi Univ Chinese Med, Sch Med Technol, Xianyang, Peoples R China; [He, Jinglan] Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China; [Gu, Yue-Wen; Fan, Jing-Wen] Fourth Mil Med Univ, Dept Clin Psychol, Xi'an, Peoples R China; [Yu, Renqiang] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China"

通信作者："Yang, L; Guo, SL (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Pulm & Crit Care Med, Chongqing, Peoples R China.; Yu, RQ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China."

来源：FRONTIERS IN NEUROSCIENCE

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000803931400001

JCR分区：Q2

影响因子：4.3

年份：2022

卷号：16

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：pulmonary nodules; anxiety; arterial spin labeling; cerebral blood flow; cerebral perfusion

摘要："Background and PurposeThe proportion of patients with somatic diseases associated with anxiety is increasing each year, and pulmonary nodules have become a non-negligible cause of anxiety, the mechanism of which is unclear. The study focus on the cerebral blood flow (CBF) of anxiety in patients with pulmonary nodules to explore the cerebral perfusion pattern of anxiety associated with pulmonary nodules, blood perfusion status and mode of pulmonary nodule induced anxiety state. Materials and MethodsPatients with unconfirmed pulmonary nodules were evaluated by Hamilton Anxiety Scale (HAMA). The total score > 14 was defined as anxiety group, and the total score <= 14 points was defined as non-anxiety group. A total of 38 patients were enrolled, of which 19 patients were the anxiety group and 19 were the non-anxiety group. All subjects underwent arterial spin labeling imaging using a 3.0 T MRI. A two-sample t-test was performed to compare the CBF between the two groups. The CBF was extracted in brain regions with difference, and Spearman correlation was used to analyze the correlation between CBF and HAMA scores; ROC was used to analyze the performance of CBF to distinguish between the anxiety group and the non-anxiety group. ResultsThe CBF in the right insula/Heschl's cortex of the anxiety group decreased (cluster = 109, peak t = 4.124, and P < 0.001), and the CBF in the right postcentral gyrus increased (cluster = 53, peak t = -3.912, and P < 0.001) in the anxiety group. But there was no correlation between CBF and HAMA score. The ROC analysis of the CBF of the right insula/Heschl's cortex showed that the AUC was 0.856 (95%CI, 0.729, 0.983; P < 0.001), the optimal cutoff value of the CBF was 50.899, with the sensitivity of 0.895, and specificity of 0.789. The ROC analysis of CBF in the right postcentral gyrus showed that the AUC was 0.845 (95%CI, 0.718, 0.972; P < 0.001), the optimal cutoff value of CBF was 43.595, with the sensitivity of 0.737, and specificity of 0.842. ConclusionThe CBF of the right insula/Heschl's cortex decreased and the CBF of the right postcentral gyrus increased in patients with pulmonary nodules under anxiety state, and the CBF of the aforementioned brain regions can accurately distinguish the anxiety group from the non-anxiety group."

基金机构："Fourth Military Medical University [2021JSTS30]; Chongqing Science and Technology Commission, Chongqing People's Municipal Government [cstc2019jscx-msxmX0184, CSTC2021jscx-gksb-N0023]; Chongqing Research project on key disease prevention and control technology [2019ZX002]; Chongqing Pulmonary Nodule Management Studio; Hospital of Chongqing Medical University [XKST134]"

基金资助正文："This work was supported by: (1) the Fourth Military Medical University (2021JSTS30); (2) Chongqing Science and Technology Commission, Chongqing People's Municipal Government (cstc2019jscx-msxmX0184 and CSTC2021jscx-gksb-N0023); (3) Chongqing Research project on key disease prevention and control technology (2019ZX002); (4) Chongqing Pulmonary Nodule Management Studio; and (5) Discipline Innovation Fund discipline training project of the First Affiliated Hospital of Chongqing Medical University (XKST134)."