Serum Dickkopf-1 levels and poststroke depression in ischemic stroke patients

作者全名："Zhang, Kaixin; Zhu, Zhengbao; Shi, Mengyao; Guo, Daoxia; Liu, Yang; Bu, Xiaoqing; Che, Bizhong; Xu, Tian; Yang, Pinni; Chen, Jing; Xu, Tan; He, Jiang; Zhang, Yonghong"

作者地址："[Zhang, Kaixin; Zhu, Zhengbao; Shi, Mengyao; Guo, Daoxia; Che, Bizhong; Yang, Pinni; Xu, Tan; Zhang, Yonghong] Soochow Univ, Sch Publ Hlth, Dept Epidemiol, Med Coll, Suzhou, Peoples R China; [Shi, Mengyao; Chen, Jing; He, Jiang] Tulane Univ, Dept Epidemiol, Sch Publ Hlth & Trop Med, New Orleans, LA USA; [Liu, Yang] Soochow Univ, Dept Cardiol, Affiliated Hosp 1, Suzhou, Peoples R China; [Bu, Xiaoqing] Chongqing Med Univ, Sch Publ Hlth & Management, Dept Epidemiol, Chongqing, Peoples R China; [Xu, Tian] Nantong Univ, Dept Neurol, Affiliated Hosp, Nantong, Peoples R China; [Chen, Jing; He, Jiang] Tulane Univ, Dept Med, Sch Med, New Orleans, LA USA; [Zhang, Kaixin; Zhu, Zhengbao; Shi, Mengyao; Guo, Daoxia; Che, Bizhong; Yang, Pinni; Xu, Tan; Zhang, Yonghong] Soochow Univ, Jiangsu Key Lab Prevent & Translat Med Geriatr Dis, Med Coll, Med Coll, 199 Renai Rd, Suzhou 215123, Peoples R China; [Zhang, Yonghong] Soochow Univ, Jiangsu Key Lab Prevent & Translat Med Geriatr Dis, Med Coll, 199 Renai Rd, Suzhou 215123, Peoples R China"

通信作者："Zhang, YH (通讯作者)，Soochow Univ, Jiangsu Key Lab Prevent & Translat Med Geriatr Dis, Med Coll, Med Coll, 199 Renai Rd, Suzhou 215123, Peoples R China.; Zhang, YH (通讯作者)，Soochow Univ, Jiangsu Key Lab Prevent & Translat Med Geriatr Dis, Med Coll, 199 Renai Rd, Suzhou 215123, Peoples R China."

来源：JOURNAL OF AFFECTIVE DISORDERS

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:000805041000002

JCR分区：Q1

影响因子：6.6

年份：2022

卷号：310

期号：　

开始页：337

结束页：342

文献类型：Article

关键词：Ischemic stroke; Poststroke depression; Dickkopf-1; Biomarker

摘要："Background: Serum Dickkopf-1 (Dkk-1) levels are associated with poor ischemic stroke prognosis, although their impact on poststroke depression (PSD) remains unclear. This study aimed to examine the association between serum Dkk-1 levels and PSD. Methods: Serum Dkk-1 levels were measured in 564 patients with ischemic stroke who participated in the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS). The patients' depression status at 3 months after stroke was assessed using the Hamilton Rating Scale for Depression (HRSD-24). The HRSD score cutoff point for the diagnosis of depression was >= 8. Results: A total of 224 (39.72%) patients were categorized as having PSD 3 months after ischemic stroke. After adjusting for potential confounders, including age, sex, and other important covariates, elevated Dkk-1 levels were associated with an increased risk of PSD (odds ratio [OR], 1.92; 95% confidence interval [CI], 1.14-3.22; P-trend = 0.037). Similarly, each standard deviation (SD) increase in log-transformed Dkk-1 levels was associated with a 24% increased risk of PSD (OR, 1.24; 95% CI, 1.03-1.49; P = 0.025). Subgroup analyses further confirmed the significant associations between Dkk-1 levels and PSD. Conclusion: Higher serum Dkk-1 levels at baseline are independently associated with an increased risk of PSD at 3 months after stroke, suggesting that Dkk-1 levels may be a promising prognostic biomarker for PSD. Limitations: This study measured serum Dkk-1 levels only in the acute phase of stroke not in different phases; therefore, the relationship between dynamic changes in Dkk-1 levels and PSD could not be evaluated."

基金机构："National Natural Science Foundation of China [82103917, 82020108028]; Natural Science Research Project of Jiangsu Provincial Higher Education [21KJB330006]; Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions, China"

基金资助正文："This study was supported by the National Natural Science Foundation of China (grants: 82103917 and 82020108028), the Natural Science Research Project of Jiangsu Provincial Higher Education (grant: 21KJB330006), and a Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions, China."