Recent evidence in support of traditional chinese medicine to restore normal leptin function in simple obesity

作者全名："Shao, Jialin; Li, Chen; Bai, Litao; Ni, Xiaolin; Ge, Shaoqin; Zhang, Jinghui; Zhao, Hanqing"

作者地址："[Shao, Jialin; Ge, Shaoqin; Zhang, Jinghui; Zhao, Hanqing] Hebei Univ, Coll Tradit Chinese Med, Baoding, Peoples R China; [Li, Chen] China Acad Chinese Med Sci, Inst Informat Tradit Chinese Med, Beijing, Peoples R China; [Bai, Litao] Chongqing Med Univ, Affiliated Hosp 2, Chongqing, Peoples R China; [Ni, Xiaolin] Natl Hlth Commiss, Natl Ctr Gerontol, Beijing Inst Geriatr, Key Lab Geriatr,Beijing Hosp, Beijing, Peoples R China; [Ni, Xiaolin] Chinese Acad Med Sci, Inst Geriatr Med, Beijing, Peoples R China; [Ni, Xiaolin] Chinese Acad Med Sci & Peking Union Med Coll, Grad Sch, Beijing, Peoples R China"

通信作者："Zhao, HQ (通讯作者)，Hebei Univ, Coll Tradit Chinese Med, Baoding, Peoples R China."

来源：HELIYON

ESI学科分类：　

WOS号：WOS:000805187600030

JCR分区：Q2

影响因子：4

年份：2022

卷号：8

期号：5

开始页：　

结束页：　

文献类型：Review

关键词：Obesity; Leptin resistance; Network pharmacology; Chinese herbal compound; Food intake

摘要："Reducing the incidence of obesity is the focus of global attention, and traditional Chinese medicine (TCM) may play an important role in achieving this goal. Numerous studies have shown that most individuals with obesity have leptin resistance, exogenous leptin is ineffective in individuals with obesity, and the effect of leptin decreases with increased serum leptin levels in individuals with obesity. At present, there are many hypotheses regarding the mechanism of leptin resistance, but there is no definite conclusion. TCM has a long history of treating obesity, and single and compound TCM is an effective obesity treatment method. However, TCM's mechanism of action is complex and resists further weight loss drug development. In the last decade, network pharmacology has become an important tool for exploring the mechanism of compound TCMs. In this study, we reviewed the interrelation between TCM obesity treatment and leptin resistance, and network pharmacology studies of TCM intervention in simple obesity revealed that their targets overlap with the leptin pathway. We also summarized TCM pairs that effectively interfere with leptin resistance and their related intervention mechanisms, providing targets for anti obesity drug development."

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