LncRNA ENSMUST_147219 mediates the progression of ischemic acute kidney injury by targeting the miR-221-5p/IRF6 axis

作者全名："Liu, Jing; Li, Xiaozhou; Yang, Jurong; Zhang, Dongshan"

作者地址："[Liu, Jing; Yang, Jurong] Chongqing Med Univ, Dept Nephrol, Affiliated Hosp 3, Chongqing 401120, Peoples R China; [Liu, Jing; Li, Xiaozhou; Zhang, Dongshan] Cent South Univ, Dept Emergency Med, Xiangya Hosp 2, Changsha, Hunan, Peoples R China; [Liu, Jing; Li, Xiaozhou; Zhang, Dongshan] Cent South Univ, Emergency Med & Difficult Dis Inst, Xiangya Hosp 2, Changsha, Hunan, Peoples R China; [Zhang, Dongshan] Cent South Univ, Xiangya Hosp 2, Dept Nephrol, Changsha 410011, Hunan, Peoples R China"

通信作者："Yang, JR (通讯作者)，Chongqing Med Univ, Dept Nephrol, Affiliated Hosp 3, Chongqing 401120, Peoples R China.; Zhang, DS (通讯作者)，Cent South Univ, Dept Emergency Med, Xiangya Hosp 2, Changsha, Hunan, Peoples R China.; Zhang, DS (通讯作者)，Cent South Univ, Emergency Med & Difficult Dis Inst, Xiangya Hosp 2, Changsha, Hunan, Peoples R China.; Zhang, DS (通讯作者)，Cent South Univ, Xiangya Hosp 2, Dept Nephrol, Changsha 410011, Hunan, Peoples R China."

来源：APOPTOSIS

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000805462900001

JCR分区：Q2

影响因子：7.2

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：AKI; LncRNA; miR-221-5p; IRF6; Apoptosis

摘要："Although previous studies have revealed that long noncoding RNAs (lncRNAs) regulate the progression of ischemic acute kidney injury (AKI), the exact role and mechanism of lncRNA ENSMUST_147219 in ischemic AKI are not clear. In the present study, lncRNA ENSMUST_147219 was induced by ischemic injury in vitro and in vivo. Functionally, lncRNA ENSMUST_147219 mediated apoptosis in mouse proximal tubule-derived cell line (BUMPT). Mechanistically, lncRNA ENSMUST_147219 sponged the microRNA (miR)-221-5p to upregulate the expression of interferon regulatory factor 6 (IRF6) to drive apoptosis. Finally, knockdown of lncRNA ENSMUST_147219 markedly attenuated the ischemic AKI by targeting the miR-221-5p/IRF6 axis. Collectively, our data demonstrated that lncRNA ENSMUST_147219 promoted the development of ischemic AKI by regulating the miR-221-5p/IRF6 pathway, which could be considered a new therapeutic target for ischemic AKI."

基金机构："National Natural Science Foundation of China [81870475, 81570646, 81770951, 81770682]; Changsha Science and Technology Bureau project [kq2001039, kq1907144]; Key Project of Hunan Provincial Science and Technology Innovation [2020SK1014]; Department of Science and Technology of Hunan Province project of International Cooperation and Exchanges [2020WK2009]; China Hunan Provincial Science and Technology Department [2021sk4004]"

基金资助正文："The study was supported in part by a grant from the National Natural Science Foundation of China [Grant Nos. 81870475, 81570646, 81770951, 81770682], Changsha Science and Technology Bureau project [Grant Nos. kq2001039, kq1907144], Key Project of Hunan Provincial Science and Technology Innovation [Grant No. 2020SK1014], Department of Science and Technology of Hunan Province project of International Cooperation and Exchanges [Grant Nos. 2020WK2009], and China Hunan Provincial Science and Technology Department (Project No.: 2021sk4004)."