ZIF-based carbon dots with lysosome-Golgi transport property as visualization platform for deep tumour therapy via hierarchical size/charge dual-transform and transcytosis

作者全名："Zhang, Xianming; Jiang, Junhao; Yu, Qinghua; Zhou, Ping; Yang, Shiyu; Xia, Jiashan; Deng, Tao; Yu, Chao"

作者地址："[Zhang, Xianming; Jiang, Junhao; Yu, Qinghua; Zhou, Ping; Yang, Shiyu; Xia, Jiashan; Deng, Tao; Yu, Chao] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China; [Zhang, Xianming; Deng, Tao; Yu, Chao] Chongqing Key Lab Pharmaceut Metab Res, Chongqing 400016, Peoples R China; [Yu, Qinghua; Zhou, Ping; Yang, Shiyu; Xia, Jiashan; Deng, Tao; Yu, Chao] Chongqing Pharmacodynam Evaluat Engn Technol Res, Chongqing 400016, Peoples R China"

通信作者："Deng, T; Yu, C (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China.; Deng, T; Yu, C (通讯作者)，Chongqing Key Lab Pharmaceut Metab Res, Chongqing 400016, Peoples R China.; Deng, T; Yu, C (通讯作者)，Chongqing Pharmacodynam Evaluat Engn Technol Res, Chongqing 400016, Peoples R China."

来源：NANOSCALE

ESI学科分类：PHYSICS

WOS号：WOS:000806451600001

JCR分区：Q1

影响因子：6.7

年份：2022

卷号：14

期号：23

开始页：8510

结束页：8524

文献类型：Article

关键词：　

摘要："The poor penetration of nanomaterials in solid tumours and difficulty in monitoring their penetration depth are major obstacles in their application for the treatment of solid tumours. Herein, pH-responsive carbon dots (ZCD) based on a zeolitic imidazolate framework (ZIF-8) were fabricated to achieve the deep delivery of the chemotherapeutic doxorubicin (DOX) via a hierarchical size/charge dual-transformation and transcytosis. The as-prepared ZCD accumulated in the solid tumour and the acidic tumour microenvironment further triggered its decomposition. Firstly, ZCD was decomposed by the weakly acidic extracellular microenvironment of the solid tumour, enabling it to transform into small and neutrally charged particles. Subsequently, these particles were endocytosed by lysosomes, and further disintegrated into smaller and positively charged particles, which could target the Golgi apparatus. Consequently, ZCD delivered DOX deep into the solid tumour via a size-shrinking strategy and Golgi-mediated transcytosis, thus significantly improving its antitumour efficacy. In addition, carbonization endowed ZCD with superior fluorescence property, which was enhanced in the acidic microenvironment, thus improving the sensitivity and accuracy of ex vivo monitoring of the penetration depth of the nanomedicine in real time. Collectively, our results confirmed that the carbon dots obtained via the direct carbonization of ZIF-8 simultaneously exhibited enhanced deep penetration into solid tumours and fluorescence, which could be monitored, and that the carbonization of functional materials is effective to enhance their fluorescence, and further broaden their applications."

基金机构："Program for Youth Innovation in Future Medicine, Chongqing Medical University [W0090]"

基金资助正文："This work was financially supported by Program for Youth Innovation in Future Medicine, Chongqing Medical University (W0090)."