Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder
作者全名："Ding, Yu-Dan; Chen, Xiao; Chen, Zuo-Bing; Li, Le; Li, Xue-Ying; Castellanos, Francisco Xavier; Bai, Tong-Jian; Bo, Qi-Jing; Cao, Jun; Chang, Zhi-Kai; Chen, Guan-Mao; Chen, Ning-Xuan; Chen, Wei; Cheng, Chang; Cheng, Yu-Qi; Cui, Xi-Long; Duan, Jia; Fang, Yi-Ru; Gong, Qi-Yong; Hou, Zheng-Hua; Hu, Lan; Kuang, Li; Li, Feng; Li, Hui-Xian; Li, Kai-Ming; Li, Tao; Liu, Yan-Song; Liu, Zhe-Ning; Long, Yi-Cheng; Lu, Bin; Luo, Qing-Hua; Meng, Hua-Qing; Peng, Dai-Hui; Qiu, Hai-Tang; Qiu, Jiang; Shen, Yue-Di; Shi, Yu-Shu; Si, Tian-Mei; Tang, Yan-Qing; Wang, Chuan-Yue; Wang, Fei; Wang, Kai; Wang, Li; Wang, Xiang; Wang, Ying; Wang, Yu-Wei; Wu, Xiao-Ping; Wu, Xin-Ran; Xie, Chun-Ming; Xie, Guang-Rong; Xie, Hai-Yan; Xie, Peng; Xu, Xiu-Feng; Yang, Hong; Yang, Jian; Yao, Jia-Shu; Yao, Shu-Qiao; Yin, Ying-Ying; Yuan, Yong-Gui; Zang, Yu-Feng; Zhang, Ai-Xia; Zhang, Hong; Zhang, Ke-Rang; Zhang, Lei; Zhang, Zhi-Jun; Zhao, Jing-Ping; Zhou, Ru-Bai; Zhou, Yi-Ting; Zhu, Jun-Juan; Zhu, Zhi-Chen; Zou, Chao-Jie; Zuo, Xi-Nian; Yan, Chao-Gan; Guo, Wen-Bin"
作者地址："[Ding, Yu-Dan; Cui, Xi-Long; Liu, Zhe-Ning; Long, Yi-Cheng; Shi, Yu-Shu; Wang, Xiang; Xie, Guang-Rong; Yao, Shu-Qiao; Zhao, Jing-Ping; Guo, Wen-Bin] Cent South Univ, Dept Psychiat, Xiangya Hosp 2, Changsha, Peoples R China; [Ding, Yu-Dan; Cui, Xi-Long; Liu, Zhe-Ning; Long, Yi-Cheng; Shi, Yu-Shu; Wang, Xiang; Xie, Guang-Rong; Yao, Shu-Qiao; Zhao, Jing-Ping; Guo, Wen-Bin] Cent South Univ, Natl Clin Res Ctr Mental Disorders, Changsha, Peoples R China; [Chen, Xiao; Li, Xue-Ying; Chang, Zhi-Kai; Chen, Ning-Xuan; Li, Hui-Xian; Lu, Bin; Wang, Yu-Wei; Zhu, Zhi-Chen; Yan, Chao-Gan] Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China; [Chen, Xiao; Chang, Zhi-Kai; Chen, Ning-Xuan; Li, Hui-Xian; Lu, Bin; Wang, Yu-Wei; Zhu, Zhi-Chen; Yan, Chao-Gan] Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China; [Chen, Xiao; Yan, Chao-Gan] Chinese Acad Sci, Int Big Data Ctr Depress Res, Beijing, Peoples R China; [Chen, Zuo-Bing] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Rehabil Med, Hangzhou, Zhejiang, Peoples R China; [Li, Le] Beijing Language & Culture Univ, Ctr Cognit Sci Language, Beijing, Peoples R China; [Li, Xue-Ying] Univ Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples R China; [Li, Xue-Ying] Sino Danish Ctr Educ & Res, Beijing, Peoples R China; [Castellanos, Francisco Xavier] NYU Grossman Sch Med, Dept Child & Adolescent Psychiat, New York, NY USA; [Castellanos, Francisco Xavier] Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA; [Bai, Tong-Jian; Wang, Kai] Anhui Med Univ, Hefei, Anhui, Peoples R China; [Bo, Qi-Jing; Li, Feng; Wang, Chuan-Yue] Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China; [Cao, Jun; Hu, Lan; Kuang, Li; Luo, Qing-Hua; Meng, Hua-Qing; Qiu, Hai-Tang] Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing, Peoples R China; [Chen, Guan-Mao; Wang, Ying] Jinan Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China; [Chen, Wei; Yao, Jia-Shu] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Hangzhou, Zhejiang, Peoples R China; [Cheng, Chang; Yang, Hong] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Radiol, Hangzhou, Zhejiang, Peoples R China; [Cheng, Yu-Qi; Xu, Xiu-Feng; Zou, Chao-Jie] Kunming Med Univ, Affiliated Hosp 1, Dept Psychiat, Kunming, Yunnan, Peoples R China; [Duan, Jia; Tang, Yan-Qing; Wang, Fei] China Med Univ, Affiliated Hosp 1, Dept Psychiat, Shenyang, Liaoning, Peoples R China; [Fang, Yi-Ru; Peng, Dai-Hui; Zhou, Ru-Bai; Zhu, Jun-Juan] Shanghai Jiao Tong Univ, Dept Psychiat, Sch Med, Shanghai, Peoples R China; [Gong, Qi-Yong; Li, Kai-Ming] Sichuan Univ, Huanxi MR Res Ctr HMRRC, Dept Radiol, West China Hosp, Chengdu, Sichuan, Peoples R China; [Gong, Qi-Yong] Sichuan Univ, Psychoradiol Res Unit, West China Hosp, Chinese Acad Med Sci, Chengdu, Sichuan, Peoples R China; [Hou, Zheng-Hua; Yin, Ying-Ying; Yuan, Yong-Gui] Southeast Univ, Zhongda Hosp, Sch Med, Dept Psychosomat & Psychiat, Nanjing, Jiangsu, Peoples R China; [Li, Tao; Zhou, Yi-Ting] Sichuan Univ, West China Hosp, Mental Hlth Ctr, Chengdu, Sichuan, Peoples R China; [Liu, Yan-Song] Soochow Univ, Suzhou Psychiat Hosp, Dept Clin Psychol, Affiliated Guangji Hosp, Suzhou, Jiangsu, Peoples R China; [Qiu, Jiang; Wu, Xin-Ran] Southwest Univ, Fac Psychol, Chongqing, Peoples R China; [Shen, Yue-Di] Hangzhou Normal Univ, Affiliated Hosp, Dept Diagnost, Med Sch, Hangzhou, Zhejiang, Peoples R China; [Si, Tian-Mei; Wang, Li] Peking Univ, Peking Univ Hosp 6, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China; [Si, Tian-Mei; Wang, Li] Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China; [Wu, Xiao-Ping; Zhang, Hong] Xian Cent Hosp, Xian, Shaanxi, Peoples R China; [Xie, Chun-Ming; Zhang, Zhi-Jun] Southeast Univ, Dept Neurol, Affiliated ZhongDa Hosp, Nanjing, Jiangsu, Peoples R China; [Xie, Hai-Yan] Zhejiang Univ, Affiliated Hosp 4, Coll Med, Dept Psychiat, Yiwu, Zhejiang, Peoples R China; [Xie, Peng] Chongqing Med Univ, Inst Neurosci, Chongqing, Peoples R China; [Xie, Peng; Yang, Jian] Chongqing Key Lab Neurobiol, Chongqing, Peoples R China; [Xie, Peng] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China; [Zang, Yu-Feng] Hangzhou Normal Univ, Ctr Cognit & Brain Disorders, Inst Psychol Sci, Hangzhou, Zhejiang, Peoples R China; [Zang, Yu-Feng] Zhejiang Key Lab Res Assessment Cognit Impairment, Hangzhou, Zhejiang, Peoples R China; [Zhang, Ai-Xia] Xi An Jiao Tong Univ, Affiliated Hosp 1, Xian, Shaanxi, Peoples R China; [Zhang, Ke-Rang] Shanxi Med Univ, Hosp 1, Taiyuan, Shanxi, Peoples R China; [Zhang, Lei] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Lab Psychol Hlth & Imaging, Sch Med, Shanghai, Peoples R China; [Zuo, Xi-Nian] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China; [Zuo, Xi-Nian] Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing, Peoples R China; [Yan, Chao-Gan] Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing, Peoples R China"
通信作者："Ding, YD (通讯作者)，Cent South Univ, Dept Psychiat, Xiangya Hosp 2, Changsha, Peoples R China.; Ding, YD (通讯作者)，Cent South Univ, Natl Clin Res Ctr Mental Disorders, Changsha, Peoples R China."
来源：TRANSLATIONAL PSYCHIATRY
ESI学科分类：PSYCHIATRY/PSYCHOLOGY
WOS号：WOS:000806782600004
JCR分区：Q1
影响因子：6.8
年份：2022
卷号：12
期号：1
开始页：
结束页：
文献类型：Article
关键词：
摘要："The nucleus accumbens (NAc) is considered a hub of reward processing and a growing body of evidence has suggested its crucial role in the pathophysiology of major depressive disorder (MDD). However, inconsistent results have been reported by studies on reward network-focused resting-state functional MRI (rs-fMRI). In this study, we examined functional alterations of the NAc-based reward circuits in patients with MDD via meta- and mega-analysis. First, we performed a coordinated-based meta-analysis with a new SDM-PSI method for all up-to-date rs-fMRI studies that focused on the reward circuits of patients with MDD. Then, we tested the meta-analysis results in the REST-meta-MDD database which provided anonymous rs-fMRI data from 186 recurrent MDDs and 465 healthy controls. Decreased functional connectivity (FC) within the reward system in patients with recurrent MDD was the most robust finding in this study. We also found disrupted NAc FCs in the DMN in patients with recurrent MDD compared with healthy controls. Specifically, the combination of disrupted NAc FCs within the reward network could discriminate patients with recurrent MDD from healthy controls with an optimal accuracy of 74.7%. This study confirmed the critical role of decreased FC in the reward network in the neuropathology of MDD. Disrupted inter-network connectivity between the reward network and DMN may also have contributed to the neural mechanisms of MDD. These abnormalities have potential to serve as brain-based biomarkers for individual diagnosis to differentiate patients with recurrent MDD from healthy controls."
基金机构：National Natural Science Foundation of China [82171508]; Natural Science Foundation of Hunan [2020JJ4784]; Science and Technology Program of Hunan Province [2020SK53413]; Key-Area Research and Development Program of Guangdong Province [2018B030334001]
基金资助正文："This study was supported by grants from the National Natural Science Foundation of China (Grant No. 82171508), Natural Science Foundation of Hunan (Grant No. 2020JJ4784), Science and Technology Program of Hunan Province (Grant No. 2020SK53413), and Key-Area Research and Development Program of Guangdong Province (2018B030334001)."
