Oral supramolecular nanovectors for dual natural medicine codelivery to prevent gastric mucosal lesion

作者全名："Chen, Yun; Zhang, Min; Zhao, Hua; Liu, Yingju; Wang, Tingting; Lei, Tingting; Xiang, Xiaoyan; Lu, Luyang; Yuan, Ziyi; Xu, Jingxin; Zhang, Jingqing"

作者地址："[Chen, Yun; Zhang, Min; Zhao, Hua; Yuan, Ziyi; Xu, Jingxin; Zhang, Jingqing] Chongqing Med Univ, Sch Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing 400016, Peoples R China; [Liu, Yingju] Chongqing Med Univ, Sch Pharm, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing 400016, Peoples R China; [Wang, Tingting] Chongqing Med Univ, Expt Teaching & Management Ctr, Biochem & Mol Biol Lab, Chongqing 400016, Peoples R China; [Lei, Tingting] Ningbo Inst Drug Control, Ningbo 315100, Peoples R China; [Xiang, Xiaoyan] Peoples Hosp Kaizhou Dist, Dept Pharm, Chongqing 405400, Peoples R China; [Lu, Luyang] Southwest Minzu Univ, Coll Pharm, Chengdu 610041, Peoples R China"

通信作者："Zhang, JQ (通讯作者)，Chongqing Med Univ, Sch Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing 400016, Peoples R China."

来源：NANOSCALE

ESI学科分类：PHYSICS

WOS号：WOS:000807040400001

JCR分区：Q1

影响因子：6.7

年份：2022

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期号：　

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文献类型：Article; Early Access

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摘要："The oral administration of a single formulation loaded with more than one natural medicine to treat chronic diseases has advantages such as convenience, effectiveness, and economy. Here, using biomaterials approved by the drug administration, we fabricated supramolecular nanovectors containing dual natural medicines to prevent gastric mucosal lesions. Nanovectors exhibited superior intestinal absorption and bioavailability, which might be due to their high dispersion, good muco-adhesiveness, blood-lymph circulation transport, lipid sensing, and protective effects. Molecular docking results clarified the possible mechanisms in aspects of efflux pump (p-glycoprotein and multidrug resistance protein 1) inhibition effects, metabolic enzyme (cytochrome P450 3A4/1A2) blocking effects, serum albumin deposit effects, and dual drug interaction effects. Nanovectors decreased ethanol-induced gastric mucosal lesions by lowering the gastric ulcer index, preventing oxidative damage, decreasing interleukin-6, tumor necrosis factor-alpha and malondialdehyde, increasing glutathione, superoxide dismutase, and prostaglandin E2 levels. The interactions of inhibitor of nuclear factor-kappa B or kappa B kinase-related proteins and dual drugs or nanovector components were simulated computationally to provide an understanding of the gastro-protective action mechanism. In all, industrializable supramolecular nanovectors could effectively co-deliver dual natural medicines via the oral route by improving the pharmacokinetic behavior and exerting protective efficacy of the gastric mucosa by decreasing the oxidative stress and inflammatory level."

基金机构：National Natural Science Foundation of China [30973645]; Chongqing Science and Technology Association [2020-11]; Chongqing Education Committee [CYS21236]

基金资助正文："This research is partially supported by grants from National Natural Science Foundation of China (30973645), Chongqing Science and Technology Association (2020-11) and Chongqing Education Committee (CYS21236)."