Differential Diagnosis of Nonabsorbable Inflammatory and Malignant Subsolid Nodules with a Solid Component <= 5 mm

作者全名："He, Xiao-Qun; Li, Xian; Wu, Yan; Wu, Shun; Luo, Tian-You; Lv, Fa-Jin; Li, Qi"

作者地址："[He, Xiao-Qun; Wu, Shun; Luo, Tian-You; Lv, Fa-Jin; Li, Qi] Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Li, Xian] Chongqing Med Univ, Dept Pathol, Chongqing, Peoples R China; [Wu, Yan] Chongqing Med Univ, Sch Nursing, Chongqing, Peoples R China"

通信作者："Li, Q (通讯作者)，Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：JOURNAL OF INFLAMMATION RESEARCH

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000807538900001

JCR分区：Q3

影响因子：4.5

年份：2022

卷号：15

期号：　

开始页：1785

结束页：1796

文献类型：Article

关键词：subsolid nodule; ground-glass opacity; computed tomography; pathology

摘要："Purpose: To investigate the differential clinical and computed tomography (CT) characteristics of pulmonary nonabsorbable inflammatory and malignant subsolid nodules (SSNs) with a solid component <= 5 mm. Patients and Methods: We retrospectively analyzed 576 consecutive patients who underwent surgical resection and had SSNs with a solid component <= 5 mm on CT images. These patients were divided into inflammatory and malignant groups according to pathology. Their clinical and imaging data were analyzed and compared. Multiple logistic regression analysis was used to identify independent prognostic factors differentiating inflammatory from malignant SSNs. Furthermore, 146 consecutive patients were included as internal validation cohort to test the prediction efficiency of this model. Results: Significant differences in 11 clinical characteristics and CT features were found between both groups (P < 0.05). Presence of respiratory symptoms, distribution of middle/lower lobe, irregular shape, part-solid nodule (PSNs), CT value of ground-glass opacity (GGO) areas <-657 Hu, presence of abnormal intra-nodular vessel sign, and interlobular septal thickening were the most effective factors for diagnosing nonabsorbable inflammatory SSNs, with an AUC (95% CI), accuracy, sensitivity, and specificity of 0.843 (95% CI: 0.811-0.872), 89.76%, 72.86%, and 81.23%, respectively. The internal validation cohort obtained an AUC (95% CI), accuracy, sensitivity, and specificity of 0.830 (95% CI: 0.759-0.887), 83.56%, 73.91%, and 76.42%, respectively. Conclusion: Nonabsorbable inflammatory and malignant SSNs with a solid component <= 5 mm exhibited different clinical and imaging characteristics."

基金机构："Chongqing Science and Technology Commission [cstc2017jcyjAX0281, cstc2016shms-ztzx10002]; Chongqing Health and Family Planning Commission [2022MSXM147]"

基金资助正文："This study has received funding by Chongqing Science and Technology Commission (cstc2017jcyjAX0281 and cstc2016shms-ztzx10002) and Chongqing Health and Family Planning Commission (2022MSXM147) of China, and the sponsors had no involvement in the role of this manuscript."