Hybrid Nanofibrous Composites with Anisotropic Mechanics and Architecture for Tendon/Ligament Repair and Regeneration

作者全名："Li, Jun; Xue, Chao; Wang, Hao; Dong, Shiyan; Yang, Zhaogang; Cao, Yuting; Zhao, Binan; Cheng, Biao; Xie, Xianrui; Mo, Xiumei; Jiang, Wen; Yuan, Hengfeng; Pan, Jianfeng"

作者地址："[Li, Jun; Xue, Chao; Zhao, Binan; Cheng, Biao; Pan, Jianfeng] Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Orthoped, Shanghai 200072, Peoples R China; [Wang, Hao] Chongqing Med Univ, Affiliated Hosp 2, Dept Orthoped, Chongqing 400010, Peoples R China; [Dong, Shiyan; Yang, Zhaogang; Jiang, Wen] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA; [Cao, Yuting; Yuan, Hengfeng] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Dept Orthopaed, Shanghai 200233, Peoples R China; [Xie, Xianrui] Binzhou Med Univ, State Adm Tradit Chinese Med China, Key Lab Prescript Effect & Clin Evaluat, Sch Pharm, Yantai 264003, Peoples R China; [Mo, Xiumei] Donghua Univ, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China"

通信作者："Pan, JF (通讯作者)，Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Orthoped, Shanghai 200072, Peoples R China.; Jiang, W (通讯作者)，Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA.; Yuan, HF (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Dept Orthopaed, Shanghai 200233, Peoples R China."

来源：SMALL

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000808417000001

JCR分区：Q1

影响因子：13.3

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：anisotropic architecture; biocompatibility; mechanical durability; nanofibrous composites; tendon; ligament repair

摘要："Rupture of tendons and ligaments (T/L) is a major clinical challenge due to T/L possess anisotropic mechanical properties and hierarchical structures. Here, to imitate these characteristics, an approach is presented by fabricating hybrid nanofibrous composites. First, hybrid fiber-reinforced yarns are fabricated via successively electrospinning poly(L-lactide-co-epsilon-caprolactone) (PLCL) and gelatin (Ge) nanofibers onto polyethylene terephthalate (PET) fibers to improve biodurability and biocompatibility. Then, by comparing different manufacturing methods, the knitted structure succeeds in simulating anisotropic mechanical properties, even being stronger than natural ligaments, and possessing comfort compliance superior to clinically used ligament advanced reinforcement system (LARS) ligament. Moreover, after inoculation with tendon-derived stem cells and transplantation in vivo, hybrid nanofibrous composites are integrated with native tendons to guide surrounding tissue ingrowth due to the highly interconnected and porous structure. The knitted hybrid nanofibrous composites are also ligamentized and remodeled in vivo to promote tendon regeneration. Specifically, after the use of optimized anisotropic hybrid nanofibrous composites to repair tendon, the deposition of tendon-associated extracellular matrix proteins is more significant. Thus, this study indicates a strategy of manufacturing anisotropic hybrid nanofibrous composites with superior mechanical properties and good histocompatibility for clinical reconstruction."

基金机构："National Nature Science Foundation of China [81802144, 81702133]; Research Project of Shanghai Municipal Health Commission [20194Y0316]; Excellent Youth Training Program of Shanghai Jiaotong University Affiliated Sixth People's Hospital [ynyq202102]"

基金资助正文："J.L., C.X., and H.W. contributed equally to this work. This study was supported by the National Nature Science Foundation of China (81802144, 81702133), the Research Project of Shanghai Municipal Health Commission (Contract Grant No. 20194Y0316), and the Excellent Youth Training Program of Shanghai Jiaotong University Affiliated Sixth People's Hospital (ynyq202102)."