A Drug-Drug Multicomponent Crystal of Metformin and Dobesilate: Crystal Structure Analysis and Hygroscopicity Property

作者全名："Jiang, Lan; Hu, Xiangnan; Cai, Linhong"

作者地址："[Jiang, Lan] Chongqing Technol & Business Univ, Coll Environm & Resources, Chongqing 400067, Peoples R China; [Hu, Xiangnan; Cai, Linhong] Chongqing Med Univ, Sch Pharm, Dept Med Chem, Chongqing 400016, Peoples R China"

通信作者："Cai, LH (通讯作者)，Chongqing Med Univ, Sch Pharm, Dept Med Chem, Chongqing 400016, Peoples R China."

来源：MOLECULES

ESI学科分类：CHEMISTRY

WOS号：WOS:000808752200001

JCR分区：Q2

影响因子：4.6

年份：2022

卷号：27

期号：11

开始页：　

结束页：　

文献类型：Article

关键词：drug-drug multicomponent crystal; metformin; dobesilate; diabetic retinopathy; hydrogen-bonding interactions; hygroscopicity property

摘要："A drug-drug multicomponent crystal consisting of metformin (MET) and dobesilate (DBS) was prospectively connected by solvent cooling and evaporating co-crystallization using the multicomponent crystal strategy, not only to optimize the physicochemical properties of single drugs, but also to play a role in the cooperative effect of DBS with the potential vascular protective effects of MET against diabetic retinopathy (DR). The crystal structure analysis demonstrated that MET and DBS were coupled in a 3D supramolecular structure connected by hydrogen-bonding interactions with a molar ratio of 1:1. Almost all hydrogen bond donors and receptors of MET and DBS participated in the bonding, which hindered the combination of remaining potential hydrogen bond sites and water molecules, resulting in a lower hygroscopicity property than MET alone."

基金机构：Chongqing Science and Technology Commission [cstc2019jscx-msxmX0096]; undergraduate Everyone Innovation Program of the School of Pharmacy of Chongqing Medical University [DXSZCXM201905]

基金资助正文：The authors acknowledge the financial support received from the Chongqing Science and Technology Commission (cstc2019jscx-msxmX0096). We also appreciate that the undergraduate Everyone Innovation Program of the School of Pharmacy of Chongqing Medical University (DXSZCXM201905) provides partial financial aid for our work.