Maternal Prenatal Inflammation Increases Brain Damage Susceptibility of Lipopolysaccharide in Adult Rat Offspring via COX-2/PGD-2/DPs Pathway Activation

作者全名："Zhang, Jiahua; Yao, Peishuang; Han, Wenli; Luo, Ying; Li, Yuke; Yang, Yang; Xia, Hui; Chen, Zhihao; Chen, Qi; Wang, Hong; Yang, Lu; Li, Huan; Hu, Congli; Huang, Haifeng; Peng, Zhe; Tan, Xiaodan; Li, Miaomiao; Yang, Junqing"

作者地址："[Zhang, Jiahua; Yao, Peishuang; Luo, Ying; Li, Yuke; Yang, Yang; Xia, Hui; Chen, Zhihao; Chen, Qi; Wang, Hong; Yang, Lu; Li, Huan; Hu, Congli; Huang, Haifeng; Peng, Zhe; Tan, Xiaodan; Li, Miaomiao; Yang, Junqing] Chongqing Med Univ, Dept Pharmacol, Key Lab Biochem & Mol Pharmacol, Chongqing 400016, Peoples R China; [Han, Wenli] Chongqing Med Univ, Anim Lab Ctr, Chongqing 400016, Peoples R China"

通信作者："Yang, JQ (通讯作者)，Chongqing Med Univ, Dept Pharmacol, Key Lab Biochem & Mol Pharmacol, Chongqing 400016, Peoples R China."

来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ESI学科分类：CHEMISTRY

WOS号：WOS:000808882800001

JCR分区：Q2

影响因子：5.6

年份：2022

卷号：23

期号：11

开始页：　

结束页：　

文献类型：Article

关键词：prenatal maternal inflammation; lipopolysaccharide; central nervous system inflammation; cyclooxygenase-2; DPs

摘要："A growing body of research suggests that inflammatory insult contributes to the etiology of central nervous system diseases, such as depression, Alzheimer's disease, and so forth. However, the effect of prenatal systemic inflammation exposure on offspring brain development and cerebral susceptibility to inflammatory insult remains unknown. In this study, we utilized the prenatal inflammatory insult model in vivo and the neuronal damage model in vitro. The results obtained show that prenatal maternal inflammation exacerbates LPS-induced memory impairment, neuronal necrosis, brain inflammatory response, and significantly increases protein expressions of COX-2, DP2, APP, and A beta, while obviously decreasing that of DP1 and the exploratory behaviors of offspring rats. Meloxicam significantly inhibited memory impairment, neuronal necrosis, oxidative stress, and inflammatory response, and down-regulated the expressions of APP, A beta, COX-2, and DP2, whereas significantly increased exploring behaviors and the expression of DP1 in vivo. Collectively, these findings suggested that maternal inflammation could cause offspring suffering from inflammatory and behavioral disorders and increase the susceptibility of offspring to cerebral pathological factors, accompanied by COX-2/PGD-2/DPs pathway activation, which could be ameliorated significantly by COX-2 inhibitor meloxicam treatment."

基金机构："Natural Science Foundation of China [81070972, 30672211]; Natural Science Foundation of Chongqing, China [cstc2020jcyj-msxmX0543]"

基金资助正文："This study was supported by research grants from the Natural Science Foundation of China (No. 81070972 and No. 30672211) and Natural Science Foundation of Chongqing, China(cstc2020jcyj-msxmX0543)."