"Efficacy, Feasibility, and Safety of Endoscopic Ultrasound-guided Fine-needle Biopsy for the Diagnosis of Gastrointestinal Subepithelial Lesions A Systematic Review and Meta-analysis"

作者全名："Tan, Yandi; Tang, Xinyi; Huang, Ju; Li, Rui"

作者地址："[Tan, Yandi; Tang, Xinyi; Huang, Ju; Li, Rui] Chongqing Med Univ, Dept Ultrasonog, Affiliated Hosp 3, Shuanghu Rd, Chongqing 401120, Peoples R China"

通信作者："Tan, YD (通讯作者)，Chongqing Med Univ, Dept Ultrasonog, Affiliated Hosp 3, Shuanghu Rd, Chongqing 401120, Peoples R China."

来源：JOURNAL OF CLINICAL GASTROENTEROLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000809205800002

JCR分区：Q2

影响因子：2.9

年份：2022

卷号：56

期号：6

开始页：E283

结束页：E292

文献类型：Review

关键词：endosonography; fine-needle biopsy; subepithelial; gastrointestinal; diagnosis

摘要："Background: Endoscopic ultrasound (EUS) fine-needle biopsy (FNB) has become an efficient method for diagnosing gastrointestinal (GI) subepithelial lesions (SELs). However, recent guidelines have not regarded FNB as the primary strategy for diagnosing GI SELs. We performed this study to systematically measure the efficacy, feasibility, and safety of EUS-FNB in diagnosing GI SELs. Materials and Methods: Relevant studies were searched in PubMed and EMBASE and published after January 2015 were included. The overall rates of diagnostic yield, technical success, and adverse events were calculated as outcome measures. The Jadad scale and the Newcastle-Ottawa scale were used to evaluate the quality of the trials, funnel plots and Egger's test were used to measure publication bias, and sensitivity and subgroup analyses were performed to explore the variance of heterogeneity and sensitivity, respectively. Results: Sixteen studies analyzing 969 patients between 2015 and 2020 were included. Studies showed little change in sensitivity, and 13 were considered high quality. A certain degree of publication bias existed in the diagnostic accuracy rate. The overall rates of diagnostic yield, technical success, and adverse events were [85.69% (95% confidence interval (CI): 82.73-88.22, I (2)=41.8%), 98.83% (95% CI: 96.73-99.97, I (2)=54.3%), and 1.26% (95% CI: 0.35-2.54, I (2)=0.0%)]. No clinical influencing factors were identified in the subgroup analysis. Conclusions: EUS-FNB is a promising technology with a relatively superior diagnostic yield, technical success, and security, which is an optimal option for the diagnosis of SELs."

基金机构：Research Incubation Project of the Third Affiliated Hospital of Chongqing Medical University [KY08025]; Basic Research and Frontier Exploration Project of Yuzhong District of Chongqing [20190107]; Chongqing Talent Plan [cstc2021ycjhbgzxm0077]

基金资助正文："This study was supported by Research Incubation Project of the Third Affiliated Hospital of Chongqing Medical University (KY08025), Basic Research and Frontier Exploration Project of Yuzhong District of Chongqing (20190107) and Chongqing Talent Plan (cstc2021ycjhbgzxm0077)."