Neurodevelopmental domain characteristics and their association with core symptoms in preschoolers with autism spectrum disorder in China: a nationwide multicenter study

作者全名："Zhang, Qian; Li, Qiu; Yang, Ting; Chen, Li; Dai, Ying; Wei, Hua; Wang, Ke; Jia, Feiyong; Wu, Lijie; Hao, Yan; Li, Ling; Zhang, Jie; Ke, Xiaoyan; Yi, Mingji; Hong, Qi; Chen, Jinjin; Fang, Shuanfeng; Wang, Yichao; Wang, Qi; Jin, Chunhua; Chen, Jie; Li, Tingyu"

作者地址："[Zhang, Qian; Li, Qiu; Yang, Ting; Chen, Li; Dai, Ying; Wei, Hua; Chen, Jie; Li, Tingyu] Chongqing Med Univ, Childrens Hosp,Chongqing Key Lab Child Hlth & Nut, Natl Clin Res Ctr Child Hlth & Disorders,Minist E, Dept Child Hlth Care,Key Lab Child Dev & Disorder, Chongqing 400014, Peoples R China; [Wang, Ke] Chongqing Med Univ, Childrens Hosp, Childrens Med Big Data Intelligent Applicat Chong, Chongqing 400014, Peoples R China; [Jia, Feiyong] First Hosp Jilin Univ, Dept Dev & Behav Pediat, Changchun 130021, Peoples R China; [Wu, Lijie] Harbin Med Univ, Publ Hlth Coll, Dept Childrens & Adolescent Hlth, Harbin 150081, Peoples R China; [Hao, Yan] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pediat, Wuhan 430030, Peoples R China; [Li, Ling] Hainan Women & Childrens Med Ctr, Dept Children Rehabil, Haikou 570100, Hainan, Peoples R China; [Zhang, Jie] Xian Childrens Hosp, Xian 710003, Peoples R China; [Ke, Xiaoyan] Nanjing Brain Hosp, Child Mental Hlth Res Ctr, Nanjing 210013, Peoples R China; [Yi, Mingji] Qingdao Univ, Affiliated Hosp, Dept Child Hlth Care, Qingdao 266003, Peoples R China; [Hong, Qi] Maternal & Child Hlth Hosp Baoan, Shenzhen 518133, Peoples R China; [Chen, Jinjin] Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Dept Child Healthcare, Shanghai 200040, Peoples R China; [Fang, Shuanfeng] Zhengzhou Univ, Childrens Hosp, Zhengzhou 450053, Peoples R China; [Wang, Yichao] Hunan Prov Maternal & Child Hlth Care Hosp, NHC Key Lab Birth Defect Res & Prevent, Changsha 410008, Peoples R China; [Wang, Qi] Deyang Matern & Child Healthcare Hosp, Deyang 618000, Sichuan, Peoples R China; [Jin, Chunhua] Capital Inst Pediat, Dept Children Hlth Care, Beijing 100020, Peoples R China"

通信作者："Chen, J; Li, TY (通讯作者)，Chongqing Med Univ, Childrens Hosp,Chongqing Key Lab Child Hlth & Nut, Natl Clin Res Ctr Child Hlth & Disorders,Minist E, Dept Child Hlth Care,Key Lab Child Dev & Disorder, Chongqing 400014, Peoples R China."

来源：BMC PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:000810668500004

JCR分区：Q2

影响因子：4.4

年份：2022

卷号：22

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Autism; Preschool children; Functional development; Core symptoms; Multicenter

摘要："Background: Autism spectrum disorder (ASD) is a group of clinically heterogenic neurodevelopmental disorders, with intellectual disability being one of its common comorbidities. No large-sample, multicenter study has focused on the neurodevelopmental aspect of preschoolers with ASD. This study investigated the neurodevelopmental characteristics of preschoolers with ASD in China and explored the association between them and the core symptoms. Methods: We enrolled 1019 ASD preschoolers aged 2-7 years old from 13 cities around China between May 2018 and December 2019, and used the revised Children Neuropsychological and Behavior Scale (CNBS-R2016) to assess their neurodevelopment. Their autistic core behaviors were evaluated based on their Social Responsiveness Scale (SRS), Autism Behavior Checklist (ABC), Child Autism Rating Scale (CARS), and communication warning behavior (CWB) scores in the CNBS-R2016. Results: Based on general developmental quotient (GQ) <70, 68.4% of the preschoolers with ASD had a developmental delay (DD), rated mild in 32.7% of them. The highest DD rate (>70%) was found in language and personalsocial skills, followed by fine motor skills (68.9%). Gross motor skills had the lowest DD rate (34.0%). We found that fine motor, language, and personal-social developmental quotients (DQs) were significantly lower than gross motor skills in no DD (GQ > 70), mild DD (GQ 55-69), and moderate and below DD groups (GQ <= 54). Furthermore, the DQs for language and personal-social skills were significantly lower than for gross and fine motor skills in both DD groups. The ABC, SRS, CARS, and CWB scores in the no DD group were the lowest, moderate in the mild DD group, and highest in the moderate and below DD group. Besides, negative correlations were found between the DQs of the four domains and the ABC, SRS, CARS, and CWB scores, of which the language and personal-social skills DQs had the strongest correlations. Conclusions: Preschoolers with ASD had unbalanced neurodevelopment domain patterns and their neurodevelopmental levels were negatively correlated with the autism core symptoms. Hence, pediatricians should actively evaluate the neurodevelopment of children with ASD and conduct long-term follow-up during their early childhood to promote early diagnosis and develop personalized intervention plans."

基金机构："National Natural Science Foundation of China [81771223, 81770526]; Guangzhou Key Project in ""Early diagnosis and treatment of autism spectrum disorders"" [202007030002]; Guangdong Key Project in ""Development of new tools for diagnosis and treatment of Autism"" [2018B030335001]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (No. 81771223, 81770526), the Guangzhou Key Project in ""Early diagnosis and treatment of autism spectrum disorders"" (202007030002),and the Guangdong Key Project in ""Development of new tools for diagnosis and treatment of Autism"" (2018B030335001)."