Whether Erythropoietin can be a Neuroprotective Agent against Premature Brain Injury: Cellular Mechanisms and Clinical Efficacy

作者全名："Ma, Xueling; Shi, Yuan"

作者地址："[Ma, Xueling; Shi, Yuan] Chongqing Med Univ, Childrens Hosp, Dept Neonatol, Chongqing 400014, Peoples R China; [Ma, Xueling; Shi, Yuan] Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ Key Lab Child Dev & Disorders, Chongqing 400014, Peoples R China; [Ma, Xueling; Shi, Yuan] Chongqing Key Lab Pediat, Chongqing 400014, Peoples R China"

通信作者："Shi, Y (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Neonatol, Chongqing 400014, Peoples R China.; Shi, Y (通讯作者)，Chongqing Key Lab Pediat, Chongqing 400014, Peoples R China.; Shi, Y (通讯作者)，Natl Clin Res Ctr Child Hlth & Disorders, Chongqing 400014, Peoples R China.; Shi, Y (通讯作者)，Minist Educ Key Lab Child Dev & Disorders, Chongqing 400014, Peoples R China."

来源：CURRENT NEUROPHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000811614400012

JCR分区：Q2

影响因子：5.3

年份：2022

卷号：20

期号：3

开始页：611

结束页：629

文献类型：Review

关键词：Erythropoietin; neuroprotective agent; pre-myelinating oligodendrocytes; premature brain injury; white matter injury; perinatal neuroinflammation

摘要："Preterm infants are at high risk of brain injury. With more understanding of the preterm brain injury's pathogenesis, neuroscientists are looking for more effective methods to prevent and treat it, among which erythropoietin (Epo) is considered as a prime candidate. This review tries to clarify the possible mechanisms of Epo in preterm neuroprotection and summarize updated evidence considering Epo as a pharmacological neuroprotective strategy in animal models and clinical trials. To date, various animal models have validated that Epo is an anti-apoptotic, anti-inflammatory, anti-oxidant, anti-excitotoxic, neurogenetic, erythropoietic, angiogenetic, and neurotrophic agent, thus preventing preterm brain injury. However, although the scientific rationale and preclinical data for Epo's neuroprotective effect are promising, when translated to bedside, the results vary in different studies, especially in its long-term efficacy. Based on existing evidence, it is still too early to recommend Epo as the standard treatment for preterm brain injury."

基金机构：National key research and development plan key special project of digital diagnosis and treating equipment [2018YFC0114405]

基金资助正文：This study was supported by the National key research and development plan key special project of digital diagnosis and treating equipment (2018YFC0114405).