Adenosine Kinase on Deoxyribonucleic Acid Methylation: Adenosine Receptor-Independent Pathway in Cancer Therapy

作者全名："Luo, Hao-Yun; Shen, Hai-Ying; Perkins, R. Serene; Wang, Ya-Xu"

作者地址："[Luo, Hao-Yun; Wang, Ya-Xu] Chongqing Med Univ, Chongqing, Peoples R China; [Luo, Hao-Yun; Wang, Ya-Xu] Chongqing Med Univ, Affiliated Hosp 2, Dept Gastrointestinal & Anorectal Surg, Chongqing, Peoples R China; [Shen, Hai-Ying] Legacy Res Inst, Dept Neurosci, Portland, OR USA; [Shen, Hai-Ying] Washington State Univ, Integrat Physiol & Neurosci, Vancouver, WA USA; [Perkins, R. Serene] Legacy Res Inst, Legacy Tumor Bank, Portland, OR USA; [Perkins, R. Serene] Midcolumbia Med Ctr, The Dalles, OR USA"

通信作者："Wang, YX (通讯作者)，Chongqing Med Univ, Chongqing, Peoples R China.; Wang, YX (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Gastrointestinal & Anorectal Surg, Chongqing, Peoples R China."

来源：FRONTIERS IN PHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000811676500001

JCR分区：Q1

影响因子：5.6

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：DNA methylation; adenosine; receptor-independent pathway; adenosine kinase; ADK isoforms; ADK inhibitor; cancer therapy

摘要："Methylation is an important mechanism contributing to cancer pathology. Methylation of tumor suppressor genes and oncogenes has been closely associated with tumor occurrence and development. New insights regarding the potential role of the adenosine receptor-independent pathway in the epigenetic modulation of DNA methylation offer the possibility of new interventional strategies for cancer therapy. Targeting DNA methylation of cancer-related genes is a promising therapeutic strategy; drugs like 5-Aza-2 '-deoxycytidine (5-AZA-CdR, decitabine) effectively reverse DNA methylation and cancer cell growth. However, current anti-methylation (or methylation modifiers) are associated with severe side effects; thus, there is an urgent need for safer and more specific inhibitors of DNA methylation (or DNA methylation modifiers). The adenosine signaling pathway is reported to be involved in cancer pathology and participates in the development of tumors by altering DNA methylation. Most recently, an adenosine metabolic clearance enzyme, adenosine kinase (ADK), has been shown to influence methylation on tumor suppressor genes and tumor development and progression. This review article focuses on recent updates on ADK and its two isoforms, and its actions in adenosine receptor-independent pathways, including methylation modification and epigenetic changes in cancer pathology."

基金机构：Good Samaritan Foundation of Legacy Health [750390799]; General Project of Chongqing Natural Science Foundation [cstc2021jcyj-msxmX0112]

基金资助正文：Funding The project was supported by grants from the Good Samaritan Foundation of Legacy Health: No. 750390799 (H-YS) and the General Project of Chongqing Natural Science Foundation: No. cstc2021jcyj-msxmX0112 (Y-XW).