Association of ABO blood group with respiratory disease hospitalization and severe outcomes: a retrospective cohort study in blood donors

作者全名："Su, Shu; Guo, Lingxia; Ma, Ting; Sun, Yang; Song, Aowei; Wang, Wenhua; Gu, Xiaoyun; Wu, Wenjie; Xie, Xinxin; Zhang, Leilei; Zhang, Lei; Yang, Jiangcun"

作者地址："[Su, Shu] Shaanxi Prov Peoples Hosp, Dept Transfus Med, Xi'an, Peoples R China; [Su, Shu] ChongQing Med Univ, Clin Res Management Off, Affiliated Hosp 2, Chongqing, Peoples R China; [Su, Shu; Zhang, Leilei; Zhang, Lei] Xi An Jiao Tong Univ, China Australia Joint Res Ctr Infect Dis, Sch Publ Hlth, Hlth Sci Ctr, Xi'an 710061, Shaanxi, Peoples R China; [Guo, Lingxia] Hlth Commiss Shaanxi Prov, Planning Dev & Informat Off, Xi'an, Peoples R China; [Sun, Yang; Wu, Wenjie] Shaanxi Prov Peoples Hosp Xian, Data Ctr, Xi'an, Peoples R China; [Gu, Xiaoyun; Wu, Wenjie] Shaanxi Hlth Informat Ctr, Dept Informat Technol, Xi'an, Shaanxi, Peoples R China; [Zhang, Lei] Alfred Hlth, Melbourne Sexual Hlth Ctr, Artificial Intelligence & Modelling Epidemiol Prog, Melbourne, Australia; [Zhang, Lei] Monash Univ, Fac Med, Cent Clin Sch, Melbourne, Australia; [Zhang, Lei] Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol & Biostat, Zhengzhou 450001, Henan, Peoples R China; [Yang, Jiangcun] Shaanxi Prov Peoples Hosp, Dept Transfus Med, 256 Youyi West Rd, Xi'an 710068, Peoples R China; [Zhang, Lei] Xi An Jiao Tong Univ, China Australia Joint Res Ctr Infect Dis, Sch Publ Hlth, Hlth Sci Ctr, 28 Xian Ning West Rd, Xi'an 710061, Shaanxi, Peoples R China"

通信作者："Zhang, L (通讯作者)，Xi An Jiao Tong Univ, China Australia Joint Res Ctr Infect Dis, Sch Publ Hlth, Hlth Sci Ctr, Xi'an 710061, Shaanxi, Peoples R China.; Zhang, L (通讯作者)，Alfred Hlth, Melbourne Sexual Hlth Ctr, Artificial Intelligence & Modelling Epidemiol Prog, Melbourne, Australia.; Zhang, L (通讯作者)，Monash Univ, Fac Med, Cent Clin Sch, Melbourne, Australia.; Zhang, L (通讯作者)，Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol & Biostat, Zhengzhou 450001, Henan, Peoples R China.; Yang, JC (通讯作者)，Shaanxi Prov Peoples Hosp, Dept Transfus Med, 256 Youyi West Rd, Xi'an 710068, Peoples R China.; Zhang, L (通讯作者)，Xi An Jiao Tong Univ, China Australia Joint Res Ctr Infect Dis, Sch Publ Hlth, Hlth Sci Ctr, 28 Xian Ning West Rd, Xi'an 710061, Shaanxi, Peoples R China."

来源：INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000811867600005

JCR分区：Q1

影响因子：8.4

年份：2022

卷号：122

期号：　

开始页：21

结束页：29

文献类型：Article

关键词：ABO blood group; Respiratory diseases; Hospitalization disease-category; Duration of hospitalization; Cohort study

摘要："Objectives: Environmental, socioeconomic, and genetic factors all are associated with respiratory diseases. We aimed to investigate the association between the ABO blood group and the susceptibility to respira-tory diseases.Methods: We constructed a retrospective cohort study of blood donors in Shaanxi, China between Jan-uary 1, 2012, and December 31, 2018, to investigate the impacts of the ABO blood group on the risk of hospitalization due to respiratory diseases.Results: Of 1,686,263 enrolled participants (680,788 females), 26,597 were admitted to the hospital for respiratory diseases. Compared with blood group O, blood groups A, B, and AB all demonstrated a higher risk for diseases of the upper respiratory tract (International Classification of Diseases, Tenth Revision: J30-J39) (ARR (Adjusted relative risk) 1.139, 95% confidence interval [1.106-1.225]; 1.095 [1.019-1.177]; 1.178 [1.067-1.30], respectively). Conversely, blood group A was found to have a lower risk (0.86 [0.747- 0.991]) for influenza (J09-J11) and blood group B had a lower risk for pneumonia (J12-J18) (0.911 [0.851- 0.976]) than blood group O. The duration of hospitalization was significantly different across the blood groups in J09-J11 and J30-J39 ( P < 0.05).Conclusion: The blood group appears to be a prognostic factor in differentiating the occurrence of specific respiratory diseases and duration.(c) 2022 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )"

基金机构："National Natural Science Foundation of China [81950410639]; Outstanding Young Scholars Support Program [3111500001]; Xi'an Jiaotong University Basic Research and Profession Grant [xtr022019003, xzy032020032, 20200344]; Xi'an Jiaotong University Young Scholar Support Grant [YX6J004]; Science and Technology Talent Support Program of Shaanxi Provincial People's Hospital [2021LJ-14]; Second Affiliated Hospital of ChongQing Medical University [2022ssky]"

基金资助正文："Lei Zhang is supported by the National Natural Science Foundation of China (Grant number: 81950410639); Outstanding Young Scholars Support Program (Grant number: 3111500001); Xi'an Jiaotong University Basic Research and Profession Grant (Grant number: xtr022019003, xzy032020032); Epidemiology modeling and risk assessment (Grant number: 20200344); and Xi'an Jiaotong University Young Scholar Support Grant (Grant number: YX6J004). Jiangcun Yang is supported by the 2021 Science and Technology Talent Support Program of Shaanxi Provincial People's Hospital (Grant Number: 2021LJ-14). Shu Su is supported by the 2022 Science and Technology Talent Support Program of The Second Affiliated Hospital of ChongQing Medical University (Grant Number: 2022ssky)."