Meta-Analysis of the Genetic Association between PTPN22 and CTLA-4 Variants and Risk of Uveitis

作者全名："Zhang, Jun; Zhou, Peng; Hu, Shuqiong; Qi, Jian"

作者地址："[Zhang, Jun] Chongqing Med Univ, Affiliated Hosp 1, Chongqing Key Lab Ophthalmol, Chongqing, Peoples R China; [Zhang, Jun] Chongqing Med Univ, Affiliated Hosp 1, Chongqing Eye Inst, Chongqing, Peoples R China; [Zhou, Peng] Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou, Peoples R China; [Hu, Shuqiong] Wuhan Univ, Wuhan Aier Eye Hosp, Wuhan, Peoples R China; [Qi, Jian] Army Med Univ, Daping Hosp, Dept Ophthalmol, Chongqing, Peoples R China"

通信作者："Qi, J (通讯作者)，Army Med Univ, Daping Hosp, Dept Ophthalmol, Chongqing, Peoples R China."

来源：OPHTHALMIC RESEARCH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000812179100003

JCR分区：Q2

影响因子：2.1

年份：2022

卷号：65

期号：3

开始页：264

结束页：275

文献类型：Article

关键词：Uveitis; PTPN22; CTLA-4; Polymorphism; Meta-analysis

摘要："Background: Though the risk of protein tyrosine phosphatase nonreceptor 22 (PTPN22) and cytotoxic T-lymphocyte antigen-4 (CTLA-4) genetic variants with uveitis have been developed, the combined results still remain uncertain and controversial. Objectives: The aim of this study was to perform a meta-analysis to estimate the precise association of PTPN22 (rs2488457 and rs2476601) and CTLA-4 (rs231775, rs5742909, rs4553808, and rs3087243) polymorphisms with uveitis susceptibility. Method: Five electronic databases (PubMed, Embase, Web of Science, China Biomedical Database, and China National Knowledge Infrastructure) were systematically searched for relevant literature up to July 20, 2021. All statistical analyses were evaluated by Stata 12.0 software and R programming language. Results: Our meta-results indicated that PTPN22 rs2488457 conferred positive susceptibility to uveitis (odds ratio [OR] = 1.18, 95% confidence interval [CI] = 1.02-1.38, p = 0.029). In stratified analysis by ethnicity, the rs2488457 C allele had a growing tendency toward uveitis in the Asian region (OR = 1.21, 95% CI = 1.00-1.45, p = 0.046). For CTLA-4 rs231775, subgroup analysis based on ethnicity manifested a negative association among uveitis individuals in the Africa region (OR = 0.25, 95% CI = 0.19-0.33, p < 0.001). For CTLA-4 rs4553808, subgroup analysis by the disease type revealed that the GG genotype was associated with an elevated risk of Behcet's disease (BD) (OR = 3.22, 95% CI = 1.05-9.90, p = 0.042). Conclusions: Our research revealed that PTPN22 rs2488457 conferred strong susceptibility to uveitis in general, especially in the Asian region. CTLA-4 rs231775 conveyed protection against uveitis in African populations, and CTLA-4 rs4553808 displayed an increased risk of BD. (C) 2022 The Author(s).Published by S. Karger AG, Basel"

基金机构："National Natural Science Foundation Project [81770916, 81400389]; Chongqing Science & Technology Foundation Project [cstc2014jcyjA10111]"

基金资助正文："This work was supported by the National Natural Science Foundation Project (grant number 81770916, 81400389) and Chongqing Science & Technology Foundation Project (grant number cstc2014jcyjA10111). No funding bodies had any role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."