A novel immune-related microRNA signature for prognosis of thymoma

作者全名："Wang, Bin; Xiao, He; Yang, Xin; Zeng, Ying; Zhang, Zhimin; Yang, Rui; Chen, Hang; Chen, Chuan; Chen, Junxia"

作者地址："[Wang, Bin; Yang, Rui; Chen, Hang; Chen, Junxia] Chongqing Med Univ, Dept Cell Biol & Genet, Chongqing 400016, Peoples R China; [Wang, Bin; Xiao, He; Yang, Rui; Chen, Hang; Chen, Chuan] Army Med Univ, Daping Hosp, Dept Oncol, Chongqing 400042, Peoples R China; [Yang, Xin] Army Med Univ, Daping Hosp, Dept Pathol, Chongqing 400042, Peoples R China; [Zeng, Ying] Univ Chinese Acad Sci, Chongqing Gen Hosp, Dept Pathol, Chongqing 410309, Peoples R China; [Zhang, Zhimin] Third Med Ctr PLA Gen Hosp, Dept Thorac Surg, Chongqing 100039, Peoples R China"

通信作者："Chen, JX (通讯作者)，Chongqing Med Univ, Dept Cell Biol & Genet, Chongqing 400016, Peoples R China.; Chen, C (通讯作者)，Army Med Univ, Daping Hosp, Dept Oncol, Chongqing 400042, Peoples R China."

来源：AGING-US

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000812764700011

JCR分区：Q2

影响因子：5.2

年份：2022

卷号：14

期号：11

开始页：4739

结束页：4754

文献类型：Article

关键词：immune-related microRNA signature; thymoma; biomarker-related recurrence risk score

摘要："Introduction: Immune microenvironment and microRNAs serve as common predictors for diagnosis and prognosis of tumors. Methods: Expression of 122 genes and 126 microRNAs in thymoma was obtained from TCGA database. The proportion of tumor-infiltrating cells was calculated, and IMRS was constructed. TREM2hi score was calculated before functional enrichment analysis on gene sets. Results: IMRS3, TREM2hi score, and CD8+ T lymphocyte abundance were significantly different among WHO classifications. WHO classification, Masaoka staging, and miR-130b-5p, miR-1307-3p, miR-425-5p, CD8, CD68, and CCL18 expression were prognostic factors for relapse-free survival and overall survival. IMRS3 upregulation polarized macrophages into M2, which rejected CD8+ T and other effector lymphocytes to promote thymoma malignant progression. Conclusions: BRRS may present a novel immune-related microRNA signature for TET prognosis."

基金机构："National Natural Science Foundation of China [81672536, 82173170]; Science and Technology Research Program of Chongqing Municipal Education Commission [KJZD-K202000405]; Innovation research group in Colleges and Universities Program of Chongqing Municipal Education Commission [CXQT20012]; project of the top-notch talent cultivation program for the graduate students of Chongqing Medical University [BJRC201918]"

基金资助正文："This work was supported by National Natural Science Foundation of China (No. 81672536,82173170) Science and Technology Research Program of Chongqing Municipal Education Commission (No. KJZD-K202000405), Innovation research group in Colleges and Universities Program of Chongqing Municipal Education Commission (No. CXQT20012) and the project of the top-notch talent cultivation program for the graduate students of Chongqing Medical University No.BJRC201918."