Identification of Breast Cancer Survivors With High Symptom Burden

作者全名："Whisenant, Meagan S.; Williams, Loretta A.; Mendoza, Tito; Cleeland, Charles; Chen, Tsun-Hsuan; Fisch, Michael J.; Shi, Quiling"

作者地址："[Whisenant, Meagan S.] Univ Texas Hlth Sci Ctr Houston, Jane & Robert Cizik Sch Nursing, 6901 Bertner Ave, Houston, TX 77030 USA; [Whisenant, Meagan S.; Williams, Loretta A.; Mendoza, Tito; Cleeland, Charles; Chen, Tsun-Hsuan] Univ Texas MD Anderson Canc Ctr, Dept Symptom Res, Houston, TX 77030 USA; [Fisch, Michael J.] Aim Specialty Hlth, Chicago, IL USA; [Shi, Quiling] Chongqing Med Univ, Sch Publ Hlth, Chongqing, Peoples R China"

通信作者："Whisenant, MS (通讯作者)，Univ Texas Hlth Sci Ctr Houston, Jane & Robert Cizik Sch Nursing, 6901 Bertner Ave, Houston, TX 77030 USA."

来源：CANCER NURSING

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000813748600002

JCR分区：Q2

影响因子：2.6

年份：2022

卷号：45

期号：4

开始页：253

结束页：261

文献类型：Article

关键词：Breast cancer survivorship; Cancer-related symptoms; Cognitive impairment; Fatigue; Latent Profile Analysis; Quality of Life; Sleep disturbance

摘要："Background While women diagnosed with breast cancer have increased survival when compared with other cancers, survivorship may include residual symptom burden from treatment and continuing endocrine therapies. Objective The objective of this study was to identify subgroups of breast cancer survivors experiencing similar symptom severity. Methods Participants were 498 women with breast cancer, not on active treatment. Symptom severity was self-reported using the MD Anderson Symptom Inventory. Target symptoms were included in a latent profile analysis. Factors related to subgroup membership and differences in quality of life (QOL) and functioning were explored using logistic regression. Results Mean age was 60.11 (SD, 11.32) years, 86.1% were white, and 79.1% were receiving endocrine therapy. Target symptoms included fatigue (reported at >= 5 by 22.8% of women), sleep disturbance (24.8%), and trouble remembering (17.2%). Two subgroups were identified: low symptom severity (77.0% of women) and high (23.0%). Older women (odds ratio [OR], 0.971; 95% confidence interval [CI], 0.952-0.989) and employed women (OR, 0.621; 95% CI, 0404-0.956) were less likely to be in the high subgroup; women with poorer performance status (OR, 1.653; 95% CI, 1.188-2.299) were more likely to be in the high subgroup. Women in the high subgroup reported lower QOL (P = .000) and greater interference with functioning (P = .000). Conclusions Two subgroups of women with distinct symptom severity were identified. Implications for Practice Identification of women at risk for high symptoms during survivorship may allow clinicians to intensify their approach to symptom management, thereby mitigating poor outcomes and impairments in QOL."

基金机构："National Cancer Institute of the National Institutes of Health [UG1CA189828, UG1CA233329]; Hawn Foundation Fund for Education Programs in Pain Symptom Research; Astellas; AstraZeneca; Bayer; Bristol Meyers Squibb; Eli Lily; Genentech; Merck"

基金资助正文："This study was conducted by the Eastern Cooperative Oncology GroupAmerican College of Radiology Imaging Network Cancer Research Group (Peter J. O'Dwyer, MD, and Mitchell D. Schnall, MD, PhD, group cochairs) and supported by theNational Cancer Institute of theNational Institutes ofHealth under the following award numbers: UG1CA189828, UG1CA233329, and the Hawn Foundation Fund for Education Programs in Pain Symptom Research. L.A.W. has received research grants from Astellas, AstraZeneca, Bayer, BristolMeyers Squibb, Eli Lily, Genentech, and Merck. C.C. has received research grants from Bayer and consults for Bayer. M.J.F. discloses employment by AIM Specialty Health and stock in Anthem, Inc. The other authors have no conflicts of interest to disclose."