Recent Progress in Traditional Chinese Medicines and Their Mechanism in the Treatment of Allergic Rhinitis

作者全名："Mao, Dehong; He, Zhongmei; Li, Linglong; Lei, Yuting; Xiao, Maodi; Zhang, Huimin; Zhang, Feng"

作者地址："[Mao, Dehong; He, Zhongmei; Li, Linglong; Lei, Yuting; Xiao, Maodi; Zhang, Huimin; Zhang, Feng] Chongqing Med Univ, Yongchuan Hosp Tradit Chinese Med, Dept Otolaryngol, Chongqing 402160, Peoples R China"

通信作者："Zhang, F (通讯作者)，Chongqing Med Univ, Yongchuan Hosp Tradit Chinese Med, Dept Otolaryngol, Chongqing 402160, Peoples R China."

来源：JOURNAL OF HEALTHCARE ENGINEERING

ESI学科分类：Multidisciplinary

WOS号：WOS:000814125400007

JCR分区：Q2

影响因子：3.822

年份：2022

卷号：2022

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：　

摘要："Objective. To conduct a systematic review on the mechanism of action and use of traditional Chinese medicines (TCM) in allergic rhinitis treatment. Background. Allergic rhinitis (AR) is a type I allergic disease of the immune system induced by immunoglobulin E mediated inflammation and is characterized by sneezing, nasal itching, paroxysmal nasal obstruction, mucosal edema, cough, and rhinorrhea. More than 500 million people have been affected by rhinitis worldwide in the past 20 years, leading to negative effects on health, quality of life, and social relationships. Currently, the trending medicines used in the case of AR include intranasal corticosteroids and oral H1 antihistamines, which are given as combinatorial medicines supplemented with immune therapy. These medications have been found to be very effective in either the short term or long term; however, they have been found to possess some serious side effects. Search Methodology. The information in this article on classical and traditional Chinese medications used to treat AR was derived from original papers and reviews published in Chinese and English language journals. Two Chinese databases (Wanfang and CNKI) and three English databases (Cochrane Library, PubMed, and Embase) were utilized for data gathering. Results. Traditional Chinese remedies have been identified to influence the production of cytokines such as IL-5 and IL-6, which are key mediators of eosinophilic inflammation, TNF-alpha, which stimulates TH2 cells at the site of inflammation, and NF-kappa B, which is required for cytokine and IgE antibody production. TCM has also been shown to be successful in lowering histamine levels, preserving histological changes by decreasing the thickness of the lamina propria, and downregulating the expression of Orai1, STIM1, and TRYC1, showing low expression of Ca+2 channel proteins. Conclusion. In this review, we discussed a series of classical, traditional Chinese medications, including Centipeda minima, Scutellaria baicalensis, licorice root (Glycyrrhiza uralensis), and others, as potential antiallergic agents and investigate their in vivo effect upon the production of cytokines and release of histamines for allergic rhinitis treatment."

基金机构：　

基金资助正文：