"A review on pathology, mechanism, and therapy for cerebellum and tremor in Parkinson's disease"

作者全名："Zhong, Yuke; Liu, Hang; Liu, Guohui; Zhao, Lili; Dai, Chengcheng; Liang, Yi; Du, Juncong; Zhou, Xuan; Mo, Lijuan; Tan, Changhong; Tan, Xinjie; Deng, Fen; Liu, Xi; Chen, Lifen"

作者地址："[Zhong, Yuke; Liu, Hang; Liu, Guohui; Zhao, Lili; Dai, Chengcheng; Liang, Yi; Du, Juncong; Zhou, Xuan; Mo, Lijuan; Tan, Changhong; Tan, Xinjie; Deng, Fen; Liu, Xi; Chen, Lifen] Chongqing Med Univ, Affiliated Hosp 2, Dept Neurol, Chongqing, Peoples R China"

通信作者："Liu, X; Chen, LF (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Neurol, Chongqing, Peoples R China."

来源：NPJ PARKINSONS DISEASE

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000815483500001

JCR分区：Q1

影响因子：8.7

年份：2022

卷号：8

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：　

摘要："Tremor is one of the core symptoms of Parkinson's disease (PD), but its mechanism is poorly understood. The cerebellum is a growing focus in PD-related researches and is reported to play an important role in tremor in PD. The cerebellum may participate in the modulation of tremor amplitude via cerebello-thalamo-cortical circuits. The cerebellar excitatory projections to the ventral intermediate nucleus of the thalamus may be enhanced due to PD-related changes, including dopaminergic/non-dopaminergic system abnormality, white matter damage, and deep nuclei impairment, which may contribute to dysregulation and resistance to levodopa of tremor. This review summarized the pathological, structural, and functional changes of the cerebellum in PD and discussed the role of the cerebellum in PD-related tremor, aiming to provide an overview of the cerebellum-related mechanism of tremor in PD."

基金机构："National Natural Science Foundation of China [81771391, 82001367]; Natural Science Foundation of Chongqing [cstc2021jcyj-msxmX0180]; Kuanren Talent Program of The Second Affiliated Hospital of Chongqing Medical University"

基金资助正文："This study is supported by the National Natural Science Foundation of China (grant number: 81771391, receiver: Lifen Chen; grant number: 82001367, receiver: Xi Liu), Natural Science Foundation of Chongqing (grant number: cstc2021jcyj-msxmX0180, receiver: Xi Liu), and Kuanren Talent Program of The Second Affiliated Hospital of Chongqing Medical University (receiver: Xi Liu)."