"Construction of D-A-Conjugated Covalent Organic Frameworks with Enhanced Photodynamic, Photothermal, and Nanozymatic Activities for Efficient Bacterial Inhibition"

作者全名："Yang, Gui-Ping; Meng, Xiao-Lin; Xiao, Sai-Jin; Zheng, Qiong-Qing; Tan, Quan-Gen; Liang, Ru-Ping; Zhang, Li; Zhang, Pu; Qiu, Jian-Ding"

作者地址："[Yang, Gui-Ping; Zheng, Qiong-Qing; Tan, Quan-Gen; Liang, Ru-Ping; Zhang, Li; Qiu, Jian-Ding] Nanchang Univ, Sch Chem & Chem Engn, Nanchang 330031, Jiangxi, Peoples R China; [Meng, Xiao-Lin; Zhang, Pu] Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing 400016, Peoples R China; [Xiao, Sai-Jin] East China Univ Technol ECUT, State Key Lab Nucl Resources & Environm, Nanchang 330013, Jiangxi, Peoples R China"

通信作者："Zhang, L; Qiu, JD (通讯作者)，Nanchang Univ, Sch Chem & Chem Engn, Nanchang 330031, Jiangxi, Peoples R China.; Zhang, P (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing 400016, Peoples R China."

来源：ACS APPLIED MATERIALS & INTERFACES

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000816926200001

JCR分区：Q1

影响因子：9.5

年份：2022

卷号：14

期号：24

开始页：28289

结束页：28300

文献类型：Article

关键词：covalent organic framework; photothermal therapy; photodynamic thcrapy; peroxidase-like nanozyme activity; synergistic antimicrobial activities

摘要："Bacterial infection causes serious threats to human life, especially with the appearance of antibiotic-resistant bacteria. Phototherapeutic approaches have become promising due to their noninvasiveness, few adverse effects, and high efficiency. Herein, a covalent organic framework (TAPP-BDP) with a conjugated donor-acceptor (D-A) structure has been constructed for efficient photoinduced bacteriostasis. Under the irradiation with a single near-infrared (NIR) light (lambda = 808 nm), TAPP-BDP alone involves triple and synergistic bacterial inhibition based on the integration of photodynamic, photothermal, and peroxidase-like enzymatic activities. The unique D-A structure endows TAPP-BDP with a narrow energy band gap, improving its photodynamic and nanozyme activities to generate reactive oxygen species (ROS) to realize the broad-spectrum bactericidal activity. The extended pi-conjugated skeleton of TAPP-BDP results in enhanced absorption in NIR, and the remarkable photothermal activity can increase the temperature up to 65 degrees C to cause efficient bacterial degeneration. TAPP-BDP shows excellent antibacterial efficiency against both Gram-negative and Gram-positive bacteria. Animal experiments further suggest that TAPP-BDP can effectively heal wounds infected with Staphylococcus aureus in living systems."

基金机构："National Natural Science Foundation of China [21964011, 22166024, 22064001, 22036003, 21976077, 22176082, 81972020]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (21964011, 22166024, 22064001, 22036003, 21976077, 22176082, and 81972020)."