Curable congestive heart failure in patients with primary aldosteronism: two cases reports

作者全名："Chen, Zijun; Zhang, Zhe; Xi, Qianlan; Huang, Guimei; Wang, Liya"

作者地址："[Chen, Zijun; Huang, Guimei] Chongqing Med Univ, Yongchuan Hosp, Dept Cardiol, Chongqing 402160, Peoples R China; [Wang, Liya] Sixth Peoples Hosp Chongqing, Dept Gynecol & Obstet, Chongqing 400016, Peoples R China; [Zhang, Zhe] Univ Chinese Acad Sci, Chongqing Gen Hosp, Dept Hlth Management Ctr, Chongqing 401147, Peoples R China; [Xi, Qianlan] Mem Hosp West, Mem Healthcare Syst, Internal Med, Pembroke Pines, FL 33028 USA"

通信作者："Wang, LY (通讯作者)，Sixth Peoples Hosp Chongqing, Dept Gynecol & Obstet, Chongqing 400016, Peoples R China."

来源：AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000817087200022

JCR分区：Q3

影响因子：2.2

年份：2022

卷号：14

期号：4

开始页：2689

结束页：2696

文献类型：Article

关键词：Heart failure; primary aldosteronism; targeted therapy

摘要："Primary aldosteronism (PA) is characterized by overproduction of aldosterone which can lead to various target organ damage, including the cardiovascular system. There are rare case reports about PA patients with severe heart failure. We report two male patients who were admitted because of severe cardiac systolic dysfunction induced by primary aldosteronism. Their cardiac function improved significantly after target therapy. Patient A was a 33 year old male with serum aldosterone concentration (PAC) 251.3 pg/ml, renin activity (PRA) 0.04 ng/ml/h, and aldosterone-to-renin ratio (ARR) 627.5. Computed tomography (CT) revealed a tumor in the left adrenal gland, while no dominant secretion function was found in the left side after the adrenal veins sampling (lateralization index 0.99). Bilateral adrenal hyperplasia was diagnosed and spironolactone was prescribed. Left ventricular ejection fraction (LVEF) was improved from 30% to 45% at the 11-month follow-up visit. Patient B was 43 years old male with PAC 185.5 pg/ml, PRA 0.46 ng/ml/h and ARR 403.2; Captopril challenge test was positive and a microadenoma (2.7*3.2*2.8 cm) was revealed on CT. Unilateral aldosterone-producing adenoma was diagnosed. His LVEF was improved from 30% to 51% at 12 months after laparoscopic adrenalectomy. Thus, it is important to screen for PA in patients with heart failure and launch the appropriate treatment for such patients."

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