Combined Use of Autofluorescence and Indocyanine Green Fluorescence Imaging in the Identification and Evaluation of Parathyroid Glands During Total Thyroidectomy: A Randomized Controlled Trial

作者全名："Yin, Supeng; Pan, Bin; Yang, Zeyu; Tang, Mi; Mo, Hongbiao; Li, Yao; Yi, Ziying; Yin, Tingjie; Shao, Cong; Yan, Cunye; Mo, Linlong; Yuan, Yuquan; Sun, Yiceng; Zhang, Fan"

作者地址："[Yin, Supeng; Pan, Bin; Yang, Zeyu; Tang, Mi; Mo, Hongbiao; Li, Yao; Yi, Ziying; Yin, Tingjie; Shao, Cong; Yan, Cunye; Mo, Linlong; Yuan, Yuquan; Sun, Yiceng; Zhang, Fan] Chongqing Gen Hosp, Dept Breast & Thyroid Surg, Chongqing, Peoples R China; [Pan, Bin; Yuan, Yuquan] Chongqing Med Univ, Grad Sch Med, Chongqing, Peoples R China"

通信作者："Sun, YC; Zhang, F (通讯作者)，Chongqing Gen Hosp, Dept Breast & Thyroid Surg, Chongqing, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000819141300001

JCR分区：Q2

影响因子：5.2

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：parathyroid glands; near-infrared fluorescence imaging; autofluorescence; indocyanine green; thyroidectomy

摘要："Background and objectivesAccurate identification and evaluation of the parathyroid glands (PGs) intraoperatively is critical to reduce the incidence of postoperative hypoparathyroidism after total thyroidectomy. Near-infrared fluorescence imaging (NIFI), including the autofluorescence (AF) and indocyanine green fluorescence (ICGF) imaging, is a promising technique to protect PGs. This study aimed to assess whether the combined use of AF and ICGF could reduce the incidence of postoperative hypoparathyroidism and improve the identification and evaluation of PGs during total thyroidectomy. MethodsThis randomized controlled trial enrolled 180 patients who were randomized into two groups and underwent total thyroidectomy with unilateral or bilateral central lymph node dissection. In the control group, the PGs were identified and evaluated by the naked eye. In the NIFI group, AF was used to identify the PGs and ICGF was applied to assess the blood perfusion of the PGs in situ. The primary outcome was the incidence of postoperative hypoparathyroidism. The secondary outcomes included the number of identified PGs, autotransplanted PGs, and known preserved PGs in situ. ResultsThe incidence of postoperative transient hypoparathyroidism was significantly lower in the NIFI group than in the control group (27.8% vs. 43.3%, P = 0.029). More PGs were identified in the NIFI group than in the control group (3.6 +/- 0.5 vs. 3.2 +/- 0.4, P < 0.001). No significant difference was observed in the number of autotransplanted PGs between the two groups (P = 0.134). Compared with the control group, a greater number of known PGs were preserved in situ in the NIFI group (1.3 +/- 0.6 vs. 1.0 +/- 0.5, P < 0.001). In the NIFI group, only 4.5% of the patients with at least one well-perfused PG (ICG score of 2) developed postoperative hypoparathyroidism, which was significantly lower than that of the control group (34.6%, P < 0.001). ConclusionCombined use of AF and ICGF during total thyroidectomy reduces the risk of transient postoperative hypoparathyroidism, enhances the ability to identify and preserve PGs, and improves the accuracy of evaluating the perfusion of PGs during surgery."

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