Emodin inhibits U87 glioblastoma cells migration by activating aryl hydrocarbon receptor (AhR) signaling pathway

作者全名："Xu, Li; Liu, Yiyun; Chen, Yangsheng; Zhu, Ruihong; Li, Siqi; Zhang, Songyan; Zhang, Jian; Xie, Heidi Qunhui; Zhao, Bin"

作者地址："[Xu, Li; Liu, Yiyun; Chen, Yangsheng; Zhu, Ruihong; Li, Siqi; Xie, Heidi Qunhui; Zhao, Bin] Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing, Peoples R China; [Xu, Li; Liu, Yiyun; Chen, Yangsheng; Zhu, Ruihong; Li, Siqi; Xie, Heidi Qunhui; Zhao, Bin] Univ Chinese Acad Sci, Beijing, Peoples R China; [Xu, Li; Chen, Yangsheng; Zhu, Ruihong; Li, Siqi; Xie, Heidi Qunhui; Zhao, Bin] Univ Chinese Acad Sci, Inst Environm & Hlth, Hangzhou Inst Adv Study, Hangzhou, Peoples R China; [Liu, Yiyun] Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing, Peoples R China; [Zhang, Songyan; Zhang, Jian] Shenzhen Univ, Hlth Sci Ctr, Engn Lab Shenzhen Nat Small Mol Innovat Drugs, Shenzhen, Peoples R China"

通信作者："Xie, HDQH (通讯作者)，Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China."

来源：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

ESI学科分类：ENVIRONMENT/ECOLOGY

WOS号：WOS:000819830700002

JCR分区：Q1

影响因子：6.8

年份：2022

卷号：234

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Glioblastoma; Emodin; Aryl hydrocarbon receptor; Interleukin 24; Migration

摘要："Aryl hydrocarbon receptor (AhR) is a ligand-activated receptor to mediates the biological reactions of many environmental and natural compounds, which is highly expressed in glioblastoma. Although it has been reported that AhR agonist emodin can suppress some kinds of tumors, its inhibitory effect on glioblastoma migration and its relationship with AhR remain unclear. Based on the complexity of tumor pathogenesis and the tissue specificity of AhR, we hope can further understand the effect of emodin on glioblastoma and explore its mechanism. We found that the inhibitory effect of emodin on the migration of U87 glioblastoma cells increased with time, and the cell migration ability was inhibited by about 25% after 36 h exposure. In this process, emodin promoted the expression of the tumor suppressor IL24 by activating the AhR signaling pathway. Reducing the expression of AhR or IL24 by interfering RNA could block or relieve the inhibitory effect of emodin on the U87 cells migration, which indicates the inhibition of emodin on the migration of glioblastoma is mediated by the AhR-IL24 axis. Our data proved the AhR-IL24 signal axis is an important pathway for emodin to inhibit the migration of glioblastoma, and the AhR signaling pathway can be used as a key target to research the regulation effect and its mechanism of compounds on glioblastoma migration."

基金机构："National Key Research and Development Program of China [2018YFA0901101, 2018YFA0901102]; National Natural Science Foundation of China [21976201, 22076216, 21836004]; Foundation Committee of Basic and Applied Basic Research of Guangdong Province, China [2019A1515111157]"

基金资助正文："This work was supported by the National Key Research and Development Program of China (2018YFA0901101, 2018YFA0901102), the National Natural Science Foundation of China (Nos. 21976201, 22076216, 21836004), Foundation Committee of Basic and Applied Basic Research of Guangdong Province, China (2019A1515111157)."